myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematological diseases. In addition to defects in hematology and stem cell progenitors, dysfunction of the bone marrow microenvironment (BMM) participate in the pathogenesis of MDS. In addition, deregulation of the immune response by pro-inflammatory response force in low-risk MDS, whereas predominates immunosuppression in high-risk MDS.

mesenchymal stroma (MSC), a part of the BMM, which is characterized by the growth of plastic adherent and multipotentiality. They exhibit immunomodulatory properties and maintain hematopoiesis. There is conflicting evidence about the status of MDS. The purpose of this study was to characterize the MDS-MSC and evaluate the effect of 5-Azacytidine.The MSC from MDS patients and controls were cultured and marked in accordance with the International Society of Cell Therapy recommendation.

immunomodulatory properties assessed by studying the cytokine production MSD, using cytometric bead array. We evaluated the effects of 5-azacytidine at MSC cytokine production.We including 35 MDS patients and 22 controls. MSC from patients and controls were cultured and characterized. MSC of patients showed morphological differences, but there are no differences in the immunophenotype or multipotentiality. Interleukin 6 (IL-6) is the major cytokine secreted MSC. MDS-MSC produce higher levels of IL-6, IL-17, interferon gamma, or interferon-γ (IFN-γ), and tumor necrosis factor alpha (TNF-α).

In vitro treatment of 5-azacytidine induced a significant decrease in the production of IL-6 by MDS MDS-MSC-MSC.The showed increased production of pro-inflammatory cytokines. In vitro treatment with 5-azacytidine causes a significant reduction in IL-6 production by MDS-MSC, restoring the levels of IL-6 to that found in control. MSC produced inflammatory cytokines involved in the pathogenesis of MDS, which represents future potential therapeutic target. In addition, the 5-azacytidine may have the effect of stroma, modulate immune responses in MDS.

<em>5</em>-Azacytidine restores <em>interleukin</em> 6-increased production in mesenchymal stromal cells from myelodysplastic patients.
5-Azacytidine restores interleukin 6-increased production in mesenchymal stromal cells from myelodysplastic patients.

Toll-like receptor 5 signal ameliorates hepatic fibrosis by inducing interferon β-modulated interleukin -1 receptor antagonist in rats.

bacterial flagellin, is recognized by the cell surface receptor pulses like (TLR) 5, is a potent activator of many types of cells, leading to activation of the innate or adaptive immunity, which is important in regulating the fibrotic process. However, the exact role of TLR5 signaling in liver fibrogenesis are still unclear, and this study aims to explain the underlying mechanism.

Flagellin injected into hepatotoxin- and cholestatic liver fibrosis induced murine model. Flagellin-induced activation of TLR5 significantly reduce the severity of liver fibrosis. Interestingly, the level of expression of interleukin-1 receptor antagonist (IL1RN) and interferons (IFNB) rose sharply in the treatment of fibrotic liver flagellin. Consistently, in vivo activation of TLR5 signaling increased sharply IFNB and IL1RN expression in the liver.

In particular, the injection of flagellin significantly worsen the severity of liver fibrosis in IFN-α / β receptor-1 (IFNAR1) knockout mice. Furthermore, expression of the heart of IL1RN in liver fibrosis of IFNAR1 KO mice was significantly lower than that of wild-type mice. In support of these findings, the production of flagellin-mediated IL1RN not enough to alleviate the severity of fibro-inflammatory response in the hearts of IFNAR1-deficient environment.

RABBIT ANTI MOUSE INTERLEUKIN-17

MBS223970-01mg 0.1mg
EUR 635

RABBIT ANTI MOUSE INTERLEUKIN-17

MBS223970-5x01mg 5x0.1mg
EUR 2695

IL-17/Interleukin-17, Antibody

GWB-F0E090 1 ml Ask for price

Interleukin-17 (IL-17)

MBS343180-001mg 0.01mg
EUR 275

Interleukin-17 (IL-17)

MBS343180-01mg 0.1mg
EUR 710

Interleukin-17 (IL-17)

MBS343180-1mg 1mg
EUR 3220

Interleukin-17 (IL-17)

MBS343180-5x1mg 5x1mg
EUR 14325

Interleukin-17 Antibody

GWB-CD7793 0.1 mg Ask for price

Interleukin 17 (IL-17) Antibody

abx234224-100ug 100 ug
EUR 610.8

Interleukin 17 (IL-17) Antibody

abx234225-100ug 100 ug
EUR 577.2

Il17rb (untagged) - Mouse interleukin 17 receptor B (Il17rb), (10ug)

MC205843 10 µg Ask for price

Il17rd (untagged) - Mouse interleukin 17 receptor D (Il17rd), (10ug)

MC221251 10 µg Ask for price

Il17ra (untagged) - Mouse interleukin 17 receptor A (Il17ra), (10ug)

MC222257 10 µg Ask for price

Il17rc (untagged) - Mouse interleukin 17 receptor C (Il17rc), (10ug)

MC220362 10 µg Ask for price

Interleukin-17 (IL-17) Human

GWB-21DD5F 0.025 mg Ask for price

Il17rc (GFP-tagged) - Mouse interleukin 17 receptor C (Il17rc), (10ug)

MG225529 10 µg Ask for price

Il17ra (GFP-tagged) - Mouse interleukin 17 receptor A (Il17ra), (10ug)

MG226704 10 µg Ask for price

Il17rd (GFP-tagged) - Mouse interleukin 17 receptor D (Il17rd), (10ug)

MG219122 10 µg Ask for price

Rat Anti Mouse Interleukin-17 Monoclonal Antibody

DMABT-51805RM 0.5 mg
EUR 709.8
Description: Rat

Mouse Interleukin-17 Antibody

GWB-34A467 0.1 mg Ask for price

Mouse Interleukin-17 Antibody

GWB-39D1B5 0.5 mg Ask for price

Mouse Interleukin-17 Antibody

GWB-995F7F 0.5 mg Ask for price

Interleukin-17 Antibody (Biotin)

GWB-C2D0E8 0.05 mg Ask for price

Rabbit Anti Mouse Interleukin-17 Polyclonal Antibody

CPBT-68001RM 0.1 mg
EUR 659.4
Description: Rabbit

IL17RC, NT (IL17RC, Interleukin-17 receptor C, Interleukin-17 receptor homolog, Interleukin-17 receptor-like protein, ZcytoR14)

MBS6007155-02mL 0.2(mL
EUR 695

IL17RC, NT (IL17RC, Interleukin-17 receptor C, Interleukin-17 receptor homolog, Interleukin-17 receptor-like protein, ZcytoR14)

MBS6007155-5x02mL 5x0.2mL
EUR 2975

Rabbit polyclonal antibody to Interleukin-17 receptor C (interleukin 17 receptor C)

TA308112 100 µl Ask for price

Bovine Interleukin 17(IL-17)

QY-E60069 96T
EUR 511.2

Fish Interleukin 17-IL-17

QY-E160090 96T
EUR 580

Human Interleukin 17

MBS430222-0025mg 0.025mg
EUR 255

Human Interleukin 17

MBS430222-5x0025mg 5x0.025mg
EUR 990

Interleukin 17 (IL17) Antibody

20-abx131944
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Interleukin 17 (IL17) Antibody

20-abx132133
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Interleukin 17 (IL17) Antibody

20-abx132369
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Interleukin 17 (IL17) Antibody

20-abx131199
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Interleukin 17 (IL17) Antibody

20-abx131200
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Interleukin 17 (IL17) Antibody

20-abx129361
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Interleukin 17 (IL17) Antibody

20-abx177112
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Interleukin 17 (IL17) Antibody

20-abx177113
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Interleukin 17 (IL17) Antibody

20-abx177114
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Interleukin 17 (IL17) Antibody

20-abx177115
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  • 200 ug
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Interleukin 17 (IL17) Antibody

20-abx177116
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  • 200 ug
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Interleukin 17 (IL17) Antibody

20-abx173097
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  • 200 ug
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Interleukin 17 (IL17) Antibody

20-abx173098
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Interleukin 17 (IL17) Antibody

20-abx173099
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Interleukin 17 (IL17) Antibody

20-abx173100
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Interleukin 17 (IL17) Antibody

20-abx173101
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Interleukin 17 (IL17) Antibody

20-abx173102
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Interleukin 17 (IL17) Antibody

20-abx173103
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Interleukin 17 (IL17) Antibody

20-abx101188
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Interleukin 17 (IL17) Antibody

20-abx101189
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Interleukin 17 (IL17) Antibody

20-abx101190
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Interleukin 17 (IL17) Antibody

20-abx101191
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Interleukin 17 (IL17) Antibody

20-abx009109
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Interleukin 17 (IL17) Antibody

abx018011-100ug 100 ug
EUR 460.8

Interleukin 17 (IL17) Antibody

abx018669-100ul 100 ul
EUR 410.4

IL17RC, NT (IL17RC, Interleukin-17 receptor C, Interleukin-17 receptor homolog, Interleukin-17 receptor-like protein, ZcytoR14) (AP)

MBS6309970-02mL 0.2mL
EUR 980

IL17RC, NT (IL17RC, Interleukin-17 receptor C, Interleukin-17 receptor homolog, Interleukin-17 receptor-like protein, ZcytoR14) (AP)

MBS6309970-5x02mL 5x0.2mL
EUR 4250

IL17RC, NT (IL17RC, Interleukin-17 receptor C, Interleukin-17 receptor homolog, Interleukin-17 receptor-like protein, ZcytoR14) (PE)

MBS6309980-02mL 0.2mL
EUR 980

IL17RC, NT (IL17RC, Interleukin-17 receptor C, Interleukin-17 receptor homolog, Interleukin-17 receptor-like protein, ZcytoR14) (PE)

MBS6309980-5x02mL 5x0.2mL
EUR 4250

IL17RC, NT (IL17RC, Interleukin-17 receptor C, Interleukin-17 receptor homolog, Interleukin-17 receptor-like protein, ZcytoR14) (APC)

MBS6309971-02mL 0.2mL
EUR 980

IL17RC, NT (IL17RC, Interleukin-17 receptor C, Interleukin-17 receptor homolog, Interleukin-17 receptor-like protein, ZcytoR14) (APC)

MBS6309971-5x02mL 5x0.2mL
EUR 4250

IL17RC, NT (IL17RC, Interleukin-17 receptor C, Interleukin-17 receptor homolog, Interleukin-17 receptor-like protein, ZcytoR14) (Biotin)

MBS6309972-02mL 0.2mL
EUR 980

IL17RC, NT (IL17RC, Interleukin-17 receptor C, Interleukin-17 receptor homolog, Interleukin-17 receptor-like protein, ZcytoR14) (Biotin)

MBS6309972-5x02mL 5x0.2mL
EUR 4250

IL17RC, NT (IL17RC, Interleukin-17 receptor C, Interleukin-17 receptor homolog, Interleukin-17 receptor-like protein, ZcytoR14) (FITC)

MBS6309973-02mL 0.2mL
EUR 980

IL17RC, NT (IL17RC, Interleukin-17 receptor C, Interleukin-17 receptor homolog, Interleukin-17 receptor-like protein, ZcytoR14) (FITC)

MBS6309973-5x02mL 5x0.2mL
EUR 4250

Il17rc (untagged) - Mouse interleukin 17 receptor C (cDNA clone MGC:6973 IMAGE:3154616), (10ug)

MC217962 10 µg Ask for price

Il17re (untagged) - Mouse interleukin 17 receptor E (cDNA clone MGC:78046 IMAGE:6311568), (10ug)

MC218341 10 µg Ask for price

IL17RC, NT (IL17RC, Interleukin-17 receptor C, Interleukin-17 receptor homolog, Interleukin-17 receptor-like protein, ZcytoR14) (MaxLight 405)

MBS6309975-01mL 0.1mL
EUR 980

IL17RC, NT (IL17RC, Interleukin-17 receptor C, Interleukin-17 receptor homolog, Interleukin-17 receptor-like protein, ZcytoR14) (MaxLight 405)

MBS6309975-5x01mL 5x0.1mL
EUR 4250

IL17RC, NT (IL17RC, Interleukin-17 receptor C, Interleukin-17 receptor homolog, Interleukin-17 receptor-like protein, ZcytoR14) (MaxLight 490)

MBS6309976-01mL 0.1mL
EUR 980

IL17RC, NT (IL17RC, Interleukin-17 receptor C, Interleukin-17 receptor homolog, Interleukin-17 receptor-like protein, ZcytoR14) (MaxLight 490)

MBS6309976-5x01mL 5x0.1mL
EUR 4250

IL17RC, NT (IL17RC, Interleukin-17 receptor C, Interleukin-17 receptor homolog, Interleukin-17 receptor-like protein, ZcytoR14) (MaxLight 550)

MBS6309977-01mL 0.1mL
EUR 980

IL17RC, NT (IL17RC, Interleukin-17 receptor C, Interleukin-17 receptor homolog, Interleukin-17 receptor-like protein, ZcytoR14) (MaxLight 550)

MBS6309977-5x01mL 5x0.1mL
EUR 4250

IL17RC, NT (IL17RC, Interleukin-17 receptor C, Interleukin-17 receptor homolog, Interleukin-17 receptor-like protein, ZcytoR14) (MaxLight 650)

MBS6309978-01mL 0.1mL
EUR 980

IL17RC, NT (IL17RC, Interleukin-17 receptor C, Interleukin-17 receptor homolog, Interleukin-17 receptor-like protein, ZcytoR14) (MaxLight 650)

MBS6309978-5x01mL 5x0.1mL
EUR 4250

IL17RC, NT (IL17RC, Interleukin-17 receptor C, Interleukin-17 receptor homolog, Interleukin-17 receptor-like protein, ZcytoR14) (MaxLight 750)

MBS6309979-01mL 0.1mL
EUR 980

IL17RC, NT (IL17RC, Interleukin-17 receptor C, Interleukin-17 receptor homolog, Interleukin-17 receptor-like protein, ZcytoR14) (MaxLight 750)

MBS6309979-5x01mL 5x0.1mL
EUR 4250

Interleukin-17 receptor B

AP84006 1mg
EUR 2640

Interleukin-17 receptor B

AP84659 1mg
EUR 2640

Mouse Interleukin-17 Antibody (Biotin)

GWB-533266 0.5 mg Ask for price

Mouse Interleukin-17 Antibody (Biotin)

GWB-A5B1FA 0.05 mg Ask for price

Rat IL-17(Interleukin-17) ELISA Kit

ER0035 96T
EUR 571.5
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 9.375pg/ml

Rat IL-17(Interleukin-17) ELISA Kit

EKF57850-48T 48T
EUR 396.9

Rat IL-17(Interleukin-17) ELISA Kit

EKF57850-5x96T 5x96T
EUR 2693.25

Rat IL-17(Interleukin-17) ELISA Kit

EKF57850-96T 96T
EUR 567

Rat IL-17(Interleukin-17) ELISA Kit

E39ER0035 96T
EUR 595

Rabbit Anti Mouse Interleukin-17 Polyclonal Antibody,Biotin

CPBT-68000RM 50 µg
EUR 659.4
Description: Rabbit

IL-17, Interleukin-17 IL-17A, human

RC212-28 5ug
EUR 125.26

IL17RC, NT (IL17RC, Interleukin-17 receptor C, Interleukin-17 receptor homolog, Interleukin-17 receptor-like protein, ZcytoR14) (Azide free) (HRP)

MBS6309974-02mL 0.2mL
EUR 980

IL17RC, NT (IL17RC, Interleukin-17 receptor C, Interleukin-17 receptor homolog, Interleukin-17 receptor-like protein, ZcytoR14) (Azide free) (HRP)

MBS6309974-5x02mL 5x0.2mL
EUR 4250

Recombinant Human Interleukin-17 (rHuIL-17)

JOT-PR1063 2µg
EUR 205
Description: Fully biologically active when compared to standard. The ED50 as determined by the dose-dependent induction of IL-6 in primary human foreskin fibroblasts was found to be approximately 2 ng/ml., corresponding to a specific activity of > 5 x 105 units/mg.

Recombinant Human Interleukin-17 (rHuIL-17)

PR1063 2µg
EUR 158
Description: Fully biologically active when compared to standard. The ED50 as determined by the dose-dependent induction of IL-6 in primary human foreskin fibroblasts was found to be approximately 2 ng/ml., corresponding to a specific activity of > 5 x 105 units/mg.

Human Interleukin-17 (IL-17) ELISA Kit

IHUIL17KT each
EUR 702
Description: Human Interleukin-17 (IL-17) ELISA Kit

Mouse Interleukin-17 (IL-17) ELISA Kit

IMSIL17KT each
EUR 729
Description: Mouse Interleukin-17 (IL-17) ELISA Kit

Sheep IL-17 (Interleukin-17) ELISA Kit

MBS2540373-10x96StripWells 10x96-Strip-Wells
EUR 4695

Sheep IL-17 (Interleukin-17) ELISA Kit

MBS2540373-24StripWells 24-Strip-Wells
EUR 225

Sheep IL-17 (Interleukin-17) ELISA Kit

MBS2540373-48StripWells 48-Strip-Wells
EUR 540

Sheep IL-17 (Interleukin-17) ELISA Kit

MBS2540373-5x96StripWells 5x96-Strip-Wells
EUR 2615

Sheep IL-17 (Interleukin-17) ELISA Kit

MBS2540373-96StripWells 96-Strip-Wells
EUR 640

Human Interleukin-17 (IL-17) ELISA Kit

MBS8413481-1Kit 1Kit
EUR 755

Human Interleukin-17 (IL-17) ELISA Kit

MBS8413481-5x1Kit 5x1Kit
EUR 3455

Mouse Interleukin-17 (IL-17) ELISA Kit

MBS8420663-1Kit 1Kit
EUR 815

Mouse Interleukin-17 (IL-17) ELISA Kit

MBS8420663-5x1Kit 5x1Kit
EUR 3715

Interleukin 17 (IL17) Antibody (FITC)

20-abx271048
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Recombinant Dog Interleukin-17

MBS225408-0005mg 0.005mg
EUR 355

Recombinant Dog Interleukin-17

MBS225408-5x0005mg 5x0.005mg
EUR 1435

Interleukin-17 Rat Recombinant

rAP-0609 Inquiry Ask for price

Rabbit Interleukin-17, IL-17 ELISA Kit

ELA-E0063Rb 96 Tests
EUR 1113.6

Interleukin 17 Receptor (IL-17R, CTLA8, IL-17RA, Interleukin-17 Receptor A)(PE)

MBS6507819-100Tests 100Tests
EUR 775

Interleukin 17 Receptor (IL-17R, CTLA8, IL-17RA, Interleukin-17 Receptor A)(PE)

MBS6507819-5x100Tests 5x100Tests
EUR 3340

Rat Interleukin 17, IL- 17 ELISA Kit

ELA-E0063r 96 Tests
EUR 1063.2

Chicken Interleukin-17, IL-17 ELISA Kit

ELA-E0063d 96 Tests
EUR 1113.6

Porcine Interleukin-17, IL-17 ELISA Kit

ELA-E0063p 96 Tests
EUR 1113.6

Porcine interleukin-17 (IL-17) ELISA Kit

QY-E40091 96T
EUR 480

Recombinant Human Interleukin-17

IL17A-26H 10 µg
EUR 190.4
Description: Lyophilized rHuIL-17 although stable at room temperature for 3 weeks, should be stored desiccated below -18-deg-C. Upon reconstitution rHuIL-17 should be stored at 4-deg-C between 2-7 days and for future use below -18-deg-C. Aliquot to avoid repeated freeze-thaw cycles.

RECOMBINANT HUMAN INTERLEUKIN-17

MBS232286-0025mg 0.025mg
EUR 510

RECOMBINANT HUMAN INTERLEUKIN-17

MBS232286-5x0025mg 5x0.025mg
EUR 2130

Mouse Interleukin-17 Recombinant

MBS553258-001mg 0.01mg
EUR 205

Mouse Interleukin-17 Recombinant

MBS553258-005mg 0.05mg
EUR 450

Interleukin-17 Human Recombinant

rAP-0546 Inquiry Ask for price

Interleukin-17 Mouse Recombinant

rAP-0570 Inquiry Ask for price

Active Interleukin 17 (IL17)

APA063Hu01 10ug
EUR 167

Active Interleukin 17 (IL17)

4-APA063Hu01
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Description: Recombinant Human Interleukin 17 expressed in: E.coli

Active Interleukin 17 (IL17)

APA063Mu61 10ug
EUR 272

Active Interleukin 17 (IL17)

APA063Po61 10ug
EUR 280

Active Interleukin 17 (IL17)

MBS2097328-001mg 0.01mg
EUR 165

Active Interleukin 17 (IL17)

MBS2097328-005mg 0.05mg
EUR 295

Active Interleukin 17 (IL17)

MBS2097328-01mg 0.1mg
EUR 440

Active Interleukin 17 (IL17)

MBS2097328-02mg 0.2mg
EUR 535

Active Interleukin 17 (IL17)

MBS2097328-05mg 0.5mg
EUR 1020

Active Interleukin 17 (IL17)

RPU54858-100ug 100ug
EUR 514.8

Active Interleukin 17 (IL17)

RPU54858-1mg 1mg
EUR 2607.8

Active Interleukin 17 (IL17)

RPU54858-50ug 50ug
EUR 401.3

Rat IL-17 -Interleukin 17- CLIA Kit

E-CL-R0400-24Tests 24 Tests
EUR 180
Description: Sandwich

Rat IL-17 -Interleukin 17- CLIA Kit

E-CL-R0400-48Tests 48 Tests
EUR 546
Description: Sandwich

Rat IL-17 -Interleukin 17- CLIA Kit

E-CL-R0400-96Tests 96 Tests
EUR 682
Description: Sandwich

Rat IL-17 -Interleukin 17- CLIA Kit

E-CL-R0400-96Tests10 96 Tests *10
EUR 6820
Description: Sandwich

Rat IL-17 -Interleukin 17- CLIA Kit

E-CL-R0400-96Tests5 96 Tests *5
EUR 3410
Description: Sandwich

Rat IL-17 (Interleukin 17) CLIA Kit

MBS2530653-5x96Tests 5x96Tests
EUR 2565

Rat IL-17 (Interleukin 17) CLIA Kit

MBS2530653-96Tests 96Tests
EUR 560

Interleukin 17 (IL17) Antibody (Biotin)

20-abx271311
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  • 10 ug
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  • 1 mg

Interleukin 17 (IL17) Antibody (Biotin)

20-abx273050
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  • 10 ug
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  • 1 mg

Interleukin 17, Recombinant, Mouse (IL-17)

MBS650651-0005mg 0.005mg
EUR 340

Interleukin 17, Recombinant, Mouse (IL-17)

MBS650651-002mg 0.02mg
EUR 490

Interleukin 17, Recombinant, Mouse (IL-17)

MBS650651-5x002mg 5x0.02mg
EUR 2055

Rat Interleukin 17, IL-17 ELISA Kit

MBS704126-10x96StripWells 10x96-Strip-Wells
EUR 4805

Rat Interleukin 17, IL-17 ELISA Kit

MBS704126-24StripWellsLIMIT1 24-Strip-Wells(LIMIT1)
EUR 275

Rat Interleukin 17, IL-17 ELISA Kit

MBS704126-48StripWells 48-Strip-Wells
EUR 420

Rat Interleukin 17, IL-17 ELISA Kit

MBS704126-5x96StripWells 5x96-Strip-Wells
EUR 2520

Rat Interleukin 17, IL-17 ELISA Kit

MBS704126-96StripWells 96-Strip-Wells
EUR 580

Pig interleukin 17, IL-17 ELISA Kit

MBS703298-10x96StripWells 10x96-Strip-Wells
EUR 4805

Pig interleukin 17, IL-17 ELISA Kit

MBS703298-24StripWellsLIMIT1 24-Strip-Wells(LIMIT1)
EUR 275

Pig interleukin 17, IL-17 ELISA Kit

MBS703298-48StripWells 48-Strip-Wells
EUR 420

Pig interleukin 17, IL-17 ELISA Kit

MBS703298-5x96StripWells 5x96-Strip-Wells
EUR 2520

Pig interleukin 17, IL-17 ELISA Kit

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Finally, the cells were treated with IL1RN ito showed significantly decreased cellular activation and related fibrogenic response. Collectively, the manipulation of TLR5 signaling may be a promising therapeutic strategy for the treatment of liver fibrosis.