myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematological diseases. In addition to defects in hematology and stem cell progenitors, dysfunction of the bone marrow microenvironment (BMM) participate in the pathogenesis of MDS. In addition, deregulation of the immune response by pro-inflammatory response force in low-risk MDS, whereas predominates immunosuppression in high-risk MDS.

mesenchymal stroma (MSC), a part of the BMM, which is characterized by the growth of plastic adherent and multipotentiality. They exhibit immunomodulatory properties and maintain hematopoiesis. There is conflicting evidence about the status of MDS. The purpose of this study was to characterize the MDS-MSC and evaluate the effect of 5-Azacytidine.The MSC from MDS patients and controls were cultured and marked in accordance with the International Society of Cell Therapy recommendation.

immunomodulatory properties assessed by studying the cytokine production MSD, using cytometric bead array. We evaluated the effects of 5-azacytidine at MSC cytokine production.We including 35 MDS patients and 22 controls. MSC from patients and controls were cultured and characterized. MSC of patients showed morphological differences, but there are no differences in the immunophenotype or multipotentiality. Interleukin 6 (IL-6) is the major cytokine secreted MSC. MDS-MSC produce higher levels of IL-6, IL-17, interferon gamma, or interferon-γ (IFN-γ), and tumor necrosis factor alpha (TNF-α).

In vitro treatment of 5-azacytidine induced a significant decrease in the production of IL-6 by MDS MDS-MSC-MSC.The showed increased production of pro-inflammatory cytokines. In vitro treatment with 5-azacytidine causes a significant reduction in IL-6 production by MDS-MSC, restoring the levels of IL-6 to that found in control. MSC produced inflammatory cytokines involved in the pathogenesis of MDS, which represents future potential therapeutic target. In addition, the 5-azacytidine may have the effect of stroma, modulate immune responses in MDS.

<em>5</em>-Azacytidine restores <em>interleukin</em> 6-increased production in mesenchymal stromal cells from myelodysplastic patients.
5-Azacytidine restores interleukin 6-increased production in mesenchymal stromal cells from myelodysplastic patients.

Toll-like receptor 5 signal ameliorates hepatic fibrosis by inducing interferon β-modulated interleukin -1 receptor antagonist in rats.

bacterial flagellin, is recognized by the cell surface receptor pulses like (TLR) 5, is a potent activator of many types of cells, leading to activation of the innate or adaptive immunity, which is important in regulating the fibrotic process. However, the exact role of TLR5 signaling in liver fibrogenesis are still unclear, and this study aims to explain the underlying mechanism.

Flagellin injected into hepatotoxin- and cholestatic liver fibrosis induced murine model. Flagellin-induced activation of TLR5 significantly reduce the severity of liver fibrosis. Interestingly, the level of expression of interleukin-1 receptor antagonist (IL1RN) and interferons (IFNB) rose sharply in the treatment of fibrotic liver flagellin. Consistently, in vivo activation of TLR5 signaling increased sharply IFNB and IL1RN expression in the liver.

In particular, the injection of flagellin significantly worsen the severity of liver fibrosis in IFN-α / β receptor-1 (IFNAR1) knockout mice. Furthermore, expression of the heart of IL1RN in liver fibrosis of IFNAR1 KO mice was significantly lower than that of wild-type mice. In support of these findings, the production of flagellin-mediated IL1RN not enough to alleviate the severity of fibro-inflammatory response in the hearts of IFNAR1-deficient environment.

Mouse Interleukin-17 Antibody

GWB-995F7F 0.5 mg Ask for price

Mouse Interleukin-17 Antibody

GWB-34A467 0.1 mg Ask for price

Interleukin-17 Antibody (Biotin)

GWB-C2D0E8 0.05 mg Ask for price

Rat Anti Mouse Interleukin-17 Monoclonal Antibody

DMABT-51805RM 0.5 mg
EUR 1132.8

Bovine Interleukin 17(IL-17)

QY-E60069 96T
EUR 511.2

Fish Interleukin 17-IL-17

QY-E160090 96T
EUR 580

Interleukin 17 (IL17) Antibody

20-abx101188
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Interleukin 17 (IL17) Antibody

20-abx101189
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Interleukin 17 (IL17) Antibody

20-abx101190
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Interleukin 17 (IL17) Antibody

20-abx101191
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Interleukin 17 (IL17) Antibody

20-abx129361
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Interleukin 17 (IL17) Antibody

20-abx131199
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Interleukin 17 (IL17) Antibody

20-abx131200
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Interleukin 17 (IL17) Antibody

20-abx131944
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Interleukin 17 (IL17) Antibody

20-abx132133
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Interleukin 17 (IL17) Antibody

20-abx173097
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Interleukin 17 (IL17) Antibody

20-abx173098
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Interleukin 17 (IL17) Antibody

20-abx173099
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Interleukin 17 (IL17) Antibody

20-abx173100
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Interleukin 17 (IL17) Antibody

20-abx173101
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Interleukin 17 (IL17) Antibody

20-abx173102
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Interleukin 17 (IL17) Antibody

20-abx173103
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Interleukin 17 (IL17) Antibody

20-abx177112
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Interleukin 17 (IL17) Antibody

20-abx177113
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Interleukin 17 (IL17) Antibody

20-abx177114
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Interleukin 17 (IL17) Antibody

20-abx177115
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Interleukin 17 (IL17) Antibody

20-abx177116
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Interleukin 17 (IL17) Antibody

20-abx132369
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Interleukin 17 (IL17) Antibody

20-abx009109
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Interleukin 17 (IL17) Antibody

abx018011-100ug 100 ug
EUR 460.8

Interleukin 17 (IL17) Antibody

abx018669-100ul 100 ul
EUR 410.4

Rabbit polyclonal antibody to Interleukin-17 receptor C (interleukin 17 receptor C)

TA308112 100 µl Ask for price

Rabbit Anti Mouse Interleukin-17 Polyclonal Antibody

CPBT-68001RM 0.1 mg
EUR 1057.2

Il17rb (untagged) - Mouse interleukin 17 receptor B (Il17rb), (10ug)

MC205843 10 µg Ask for price

Il17rd (untagged) - Mouse interleukin 17 receptor D (Il17rd), (10ug)

MC221251 10 µg Ask for price

Il17ra (untagged) - Mouse interleukin 17 receptor A (Il17ra), (10ug)

MC222257 10 µg Ask for price

Il17rc (untagged) - Mouse interleukin 17 receptor C (Il17rc), (10ug)

MC220362 10 µg Ask for price

Interleukin-17 receptor B

AP84006 1mg
EUR 2640

Interleukin-17 receptor B

AP84659 1mg
EUR 2640

Rat IL-17(Interleukin-17) ELISA Kit

ER0035 96T
EUR 571.5
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 9.375pg/ml

Rat IL-17(Interleukin-17) ELISA Kit

EKF57850-48T 48T
EUR 396.9

Rat IL-17(Interleukin-17) ELISA Kit

EKF57850-5x96T 5x96T
EUR 2693.25

Rat IL-17(Interleukin-17) ELISA Kit

EKF57850-96T 96T
EUR 567

Rat IL-17(Interleukin-17) ELISA Kit

E39ER0035 96T
EUR 595

Mouse Interleukin-17 Antibody (Biotin)

GWB-533266 0.5 mg Ask for price

Mouse Interleukin-17 Antibody (Biotin)

GWB-A5B1FA 0.05 mg Ask for price

IL-17, Interleukin-17 IL-17A, human

RC212-28 5ug
EUR 125.26

Mouse Interleukin-17 (IL-17) ELISA Kit

IMSIL17KT each
EUR 729
Description: Mouse Interleukin-17 (IL-17) ELISA Kit

Human Interleukin-17 (IL-17) ELISA Kit

IHUIL17KT each
EUR 702
Description: Human Interleukin-17 (IL-17) ELISA Kit

Interleukin-17 Rat Recombinant

rAP-0609 Inquiry Ask for price

Rabbit Interleukin-17, IL-17 ELISA Kit

ELA-E0063Rb 96 Tests
EUR 1113.6

Interleukin 17 (IL17) Antibody (FITC)

20-abx271048
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Rat Interleukin 17, IL- 17 ELISA Kit

ELA-E0063r 96 Tests
EUR 1063.2

Active Interleukin 17 (IL17)

APA063Hu01 10ug
EUR 167

Active Interleukin 17 (IL17)

4-APA063Hu01
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Description: Recombinant Human Interleukin 17 expressed in: E.coli

Active Interleukin 17 (IL17)

APA063Mu61 10ug
EUR 272

Active Interleukin 17 (IL17)

APA063Po61 10ug
EUR 280

Active Interleukin 17 (IL17)

RPU54858-100ug 100ug
EUR 514.8

Active Interleukin 17 (IL17)

RPU54858-1mg 1mg
EUR 2607.8

Active Interleukin 17 (IL17)

RPU54858-50ug 50ug
EUR 401.3

Chicken Interleukin-17, IL-17 ELISA Kit

ELA-E0063d 96 Tests
EUR 1113.6

Porcine Interleukin-17, IL-17 ELISA Kit

ELA-E0063p 96 Tests
EUR 1113.6

Porcine interleukin-17 (IL-17) ELISA Kit

QY-E40091 96T
EUR 480

Rat Interleukin 17 (IL-17) CLIA Kit

abx195862-96tests 96 tests
EUR 990

Rat IL-17 -Interleukin 17- CLIA Kit

E-CL-R0400-24Tests 24 Tests
EUR 180
Description: Sandwich

Rat IL-17 -Interleukin 17- CLIA Kit

E-CL-R0400-48Tests 48 Tests
EUR 546
Description: Sandwich

Rat IL-17 -Interleukin 17- CLIA Kit

E-CL-R0400-96Tests 96 Tests
EUR 682
Description: Sandwich

Rat IL-17 -Interleukin 17- CLIA Kit

E-CL-R0400-96Tests10 96 Tests *10
EUR 6820
Description: Sandwich

Rat IL-17 -Interleukin 17- CLIA Kit

E-CL-R0400-96Tests5 96 Tests *5
EUR 3410
Description: Sandwich

Rabbit Anti Mouse Interleukin-17 Polyclonal Antibody,Biotin

CPBT-68000RM 50 µg
EUR 1057.2

Interleukin-17 Human Recombinant

rAP-0546 Inquiry Ask for price

Interleukin-17 Mouse Recombinant

rAP-0570 Inquiry Ask for price

Il17rd (GFP-tagged) - Mouse interleukin 17 receptor D (Il17rd), (10ug)

MG219122 10 µg Ask for price

Il17rc (GFP-tagged) - Mouse interleukin 17 receptor C (Il17rc), (10ug)

MG225529 10 µg Ask for price

Il17ra (GFP-tagged) - Mouse interleukin 17 receptor A (Il17ra), (10ug)

MG226704 10 µg Ask for price

Rat Interleukin 17 (IL-17) Elisa Kit

EK720278 96 Wells
EUR 0.55

Rat Interleukin 17(IL-17) Elisa Kit

EK720746 96 Wells
EUR 0.6

Rat IL-17 (Interleukin 17) ELISA Kit

EKE62174-5x96T 5x96T
EUR 2667.6

Rat IL-17 (Interleukin 17) ELISA Kit

EKE62174-96T 96T
EUR 561.6

Rat Interleukin 17,IL-17 ELISA KIT

EKC39259-48T 48T
EUR 412.79

Rat Interleukin 17,IL-17 ELISA KIT

EKC39259-5x96T 5x96T
EUR 2801.08

Rat Interleukin 17,IL-17 ELISA KIT

EKC39259-96T 96T
EUR 589.7

Pig interleukin 17,IL-17 ELISA Kit

EKC40375-48T 48T
EUR 412.79

Pig interleukin 17,IL-17 ELISA Kit

EKC40375-5x96T 5x96T
EUR 2801.08

Pig interleukin 17,IL-17 ELISA Kit

EKC40375-96T 96T
EUR 589.7

Rat Interleukin 17(IL-17)ELISA Kit

GA-E0124RT-48T 48T
EUR 424.8

Rat Interleukin 17(IL-17)ELISA Kit

GA-E0124RT-96T 96T
EUR 685.2

Rat Interleukin 17 (IL-17) ELISA Kit

EK11238 96Т
EUR 799

Rat Interleukin 17, IL-17 ELISA KIT

CSB-E07451r-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Rat Interleukin 17, IL-17 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Rat Interleukin 17, IL-17 ELISA KIT

1-CSB-E07451r
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  • 1 plate of 96 wells
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Description: Quantitativesandwich ELISA kit for measuring Rat Interleukin 17, IL-17 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Pig interleukin 17, IL-17 ELISA Kit

CSB-E08057p-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Pig interleukin 17, IL-17 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Pig interleukin 17, IL-17 ELISA Kit

1-CSB-E08057p
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  • 1 plate of 96 wells
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Description: Quantitativesandwich ELISA kit for measuring Pig interleukin 17, IL-17 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Rat Interleukin 17,IL-17 ELISA KIT

CN-01495R1 96T
EUR 538.8

Rat Interleukin 17,IL-17 ELISA KIT

CN-01495R2 48T
EUR 358.8

Rat Interleukin 17 (IL-17) ELISA Kit

AE58509RA-48Tests 48 Tests
EUR 260
Description: Rat (Rattus norvegicus)

Rat Interleukin 17 (IL-17) ELISA Kit

AE58509RA-96Tests 96 Tests
EUR 480
Description: Rat (Rattus norvegicus)

Pig Interleukin 17 (IL-17) ELISA Kit

RK06140 96T
EUR 280

Rat Interleukin 17(IL-17)ELISA Kit

QY-E11529 96T
EUR 433.2

Rat Interleukin 17(IL-17) ELISA Kit

NSL0429r 96 Tests
EUR 498

Rat Interleukin 17,IL-17 ELISA Kit

SL0399Ra -
EUR 498

Rat Interleukin 17,IL-17 ELISA KIT

YLA0201RA-48T 48T Ask for price

Rat Interleukin 17,IL-17 ELISA KIT

YLA0201RA-96T 96T Ask for price

Interleukin 17 (IL17) Antibody (Biotin)

20-abx271311
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Interleukin 17 (IL17) Antibody (Biotin)

20-abx273050
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Bird Interleukin 17(IL-17) Elisa Kit

EK780135 96 Wells
EUR 0.99

Human Interleukin 17 (IL-17) CLIA Kit

abx195860-96tests 96 tests
EUR 990

Mouse Interleukin 17 (IL-17) CLIA Kit

abx195861-96tests 96 tests
EUR 990

Goat Interleukin 17(IL-17) ELISA Kit

NSL0549Gt 96T
EUR 528

Goat Interleukin 17 (IL-17) ELISA Kit

SL0067Gt - Ask for price

Mouse IL-17 -Interleukin 17- CLIA Kit

E-CL-M0045-24Tests 24 Tests
EUR 180
Description: Sandwich

Mouse IL-17 -Interleukin 17- CLIA Kit

E-CL-M0045-48Tests 48 Tests
EUR 546
Description: Sandwich

Mouse IL-17 -Interleukin 17- CLIA Kit

E-CL-M0045-96Tests 96 Tests
EUR 682
Description: Sandwich

Mouse IL-17 -Interleukin 17- CLIA Kit

E-CL-M0045-96Tests10 96 Tests *10
EUR 6820
Description: Sandwich

Mouse IL-17 -Interleukin 17- CLIA Kit

E-CL-M0045-96Tests5 96 Tests *5
EUR 3410
Description: Sandwich

Human IL-17 -Interleukin 17- CLIA Kit

E-CL-H0104-24Tests 24 Tests
EUR 180
Description: Sandwich

Human IL-17 -Interleukin 17- CLIA Kit

E-CL-H0104-48Tests 48 Tests
EUR 546
Description: Sandwich

Human IL-17 -Interleukin 17- CLIA Kit

E-CL-H0104-96Tests 96 Tests
EUR 682
Description: Sandwich

Human IL-17 -Interleukin 17- CLIA Kit

E-CL-H0104-96Tests10 96 Tests *10
EUR 6820
Description: Sandwich

Human IL-17 -Interleukin 17- CLIA Kit

E-CL-H0104-96Tests5 96 Tests *5
EUR 3410
Description: Sandwich

Human Interleukin 17,IL-17 ELISA Kit

201-12-0143 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Sheep Interleukin 17(IL-17) Elisa Kit

EK770702 96 Wells
EUR 0.97

Mouse Interleukin 17(IL-17) Elisa Kit

EK730213 96 Wells
EUR 0.66

Mouse Interleukin 17,IL-17 Elisa Kit

EK731069 96 Wells
EUR 0.75

Human Interleukin 17(IL-17) Elisa Kit

EK711084 96 Wells
EUR 0.14

Mouse Interleukin 17,IL-17 ELISA Kit

EKC37153-48T 48T
EUR 412.79

Mouse Interleukin 17,IL-17 ELISA Kit

EKC37153-5x96T 5x96T
EUR 2801.08

Mouse Interleukin 17,IL-17 ELISA Kit

EKC37153-96T 96T
EUR 589.7

Human IL-17 (Interleukin 17) ELISA Kit

EKE60099-5x96T 5x96T
EUR 2667.6

Human IL-17 (Interleukin 17) ELISA Kit

EKE60099-96T 96T
EUR 561.6

Mouse IL-17 (Interleukin 17) ELISA Kit

EKE61494-5x96T 5x96T
EUR 2667.6

Mouse IL-17 (Interleukin 17) ELISA Kit

EKE61494-96T 96T
EUR 561.6

Mouse Interleukin 17(IL-17)ELISA Kit

GA-E0063MS-48T 48T
EUR 403.2

Mouse Interleukin 17(IL-17)ELISA Kit

GA-E0063MS-96T 96T
EUR 640.8

Human Interleukin 17(IL-17)ELISA Kit

GA-E0081HM-48T 48T
EUR 346.8

Human Interleukin 17(IL-17)ELISA Kit

GA-E0081HM-96T 96T
EUR 559.2

Human IL-17(Interleukin 17) ELISA Kit

E39EH3267 96T
EUR 595

Mouse IL-17(Interleukin 17) ELISA Kit

E39EM0226 96T
EUR 595

Mouse Interleukin 17 (IL-17) ELISA Kit

EK11239 96Т
EUR 799

Mouse Interleukin 17, IL-17 ELISA Kit

CSB-E04608m-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Mouse Interleukin 17, IL-17 in samples from serum, plasma, tissue homogenates, cell culture supernates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Mouse Interleukin 17, IL-17 ELISA Kit

1-CSB-E04608m
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  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Mouse Interleukin 17, IL-17 in samples from serum, plasma, tissue homogenates, cell culture supernates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Mouse Interleukin 17,IL-17 ELISA Kit

CSB-E04608m-IS 96Т
EUR 496
Description: serum, plasma, tissue homogenates, cell culture supernates

Mouse Interleukin 17 (IL-17) ELISA Kit

AE58510MO-48Tests 48 Tests
EUR 260
Description: Mouse (Mus musculus)

Mouse Interleukin 17 (IL-17) ELISA Kit

AE58510MO-96Tests 96 Tests
EUR 480
Description: Mouse (Mus musculus)

Mouse Interleukin 17,IL-17 ELISA Kit

CN-02453M1 96T
EUR 536.4

Mouse Interleukin 17,IL-17 ELISA Kit

CN-02453M2 48T
EUR 355.2

Human Interleukin 17,IL-17 ELISA Kit

CN-03335H1 96T
EUR 520.8

Human Interleukin 17,IL-17 ELISA Kit

CN-03335H2 48T
EUR 340.8

Mouse Interleukin 17(IL-17)ELISA Kit

QY-E20837 96T
EUR 433.2

Human Interleukin 17(IL-17)ELISA Kit

QY-E04323 96T
EUR 433.2

Human Interleukin 17(IL-17) ELISA Kit

NSL1920Hu 96 wells
EUR 468

Mouse Interleukin 17(IL-17)ELISA Kit

NSL1457m 96 Test
EUR 528

Mouse interleukin 17,IL-17 ELISA Kit

SL0314Mo -
EUR 528

Human Interleukin 17,IL-17 ELISA Kit

SL0978Hu 96 Tests
EUR 468

Human Interleukin 17,IL-17 ELISA Kit

YLA1538HU-48T 48T Ask for price

Human Interleukin 17,IL-17 ELISA Kit

YLA1538HU-96T 96T Ask for price

Mouse Interleukin 17,IL-17 ELISA Kit

YLA0321MO-48T 48T Ask for price

Mouse Interleukin 17,IL-17 ELISA Kit

YLA0321MO-96T 96T Ask for price

Recombinant Human Interleukin-17(rHu IL-17)

70117 25ul
EUR 235
Description: Fully biologically active when compared to standard. The ED50 as determined by inducing IL-6 secretion of murine NIH/3T3 cells is less than 7.5 ng/ml, corresponding to a specific activity of > 1.3 × 105 IU/mg.

Eukaryotic Interleukin 17 (IL17)

EPA063Hu61 10ug
EUR 264

Eukaryotic Interleukin 17 (IL17)

4-EPA063Hu61
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  • 100 ug
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  • 5 mg
Description: Recombinant Human Interleukin 17 expressed in: 293F cell

Eukaryotic Interleukin 17 (IL17)

RPU54768-100ug 100ug
EUR 812.9

Finally, the cells were treated with IL1RN ito showed significantly decreased cellular activation and related fibrogenic response. Collectively, the manipulation of TLR5 signaling may be a promising therapeutic strategy for the treatment of liver fibrosis.