Serum Ghrelin Levels in Saudi Obese Asthmatic School-Children-Correlation with Interleukin-4, Interleukin–5, and Interleukin-21.

Ghrelin is a peptide hormone with a direct or indirect effect on obesity and asthma. More data is needed to understand the effects of ghrelin on the control and pathogenesis of this disease. The purpose of this study was to evaluate the level of ghrelin in selected groups of children to identify the relationship between serum ghrelin, obesity and asthma severity. The study involved 401 school children were selected from the region of Najran and grouped into non-obese people with asthma, obese patients with asthma, obese non-asthmatics and controls (non-obese non-asthmatics). levels of ghrelin, interleukin (IL) -4, IL-5 and IL-21 were determined by ELISA.

The mean value of ghrelin were not significantly elevated in obese children compared with children of non-obese. The highest blood ghrelin values ​​are in the non-obese asthma group. Serum ghrelin, IL-4 and IL-21 levels were significantly increased in children with asthma compared with children of non-asthma (p <0.05), and there was a significant positive correlation between ghrelin and IL-4, IL -5, and IL-21 in children with asthma.

Furthermore, ghrelin, the level of IL-4 and IL-21 were significantly higher in patients with uncontrolled asthma compared to controlled-asthmatic children (p <0.05). Asthma is a significant risk factor only for values ​​higher ghrelin. This study provides evidence that supports the anti-inflammatory role of ghrelin in the pathogenesis of asthma. Asthma may be considered as an important determinant of the values ​​of ghrelin were higher in children.

Anti interleukin – 5 -neutralizing antibody attenuates cardiac injury and cardiac dysfunction by aggravating the inflammatory response in the doxorubicin-treated mice.

Previous studies have shown that interleukin (ILS) are closely associated with doxorubicin (DOX) -induced cardiac injury. IL-5 is an important member of the family IL, and the study was conducted to investigate whether IL-5 affect DOX-induced cardiac injury and the underlying mechanisms. The heart of the IL-5 expression was first detected and the results showed that the heart of IL-5 levels were significantly lowered in DOX-treated mice, and IL-5 is mainly derived from the heart mo.

In addition, some mice DOX-treated received injections of antibodies anti-IL-5-neutralizing (NAB), and we found that treatment with mouse anti-IL-5 NAB significantly up-regulated levels of markers of myocardial injury, exacerbated cardiac dysfunction, increased M1 macrophages (mO1) and a decrease in M2 macrophages (MO2) differentiation, and promoted the expression of markers of apoptosis.

In addition, the effect of mouse IL-5 TLV on differentiation mo DOX-induced and its role in cardiomyocyte rat (MCM) of apoptotic cells detected in vitro, and the results exhibited that the mouse IL-5 NAB promoted differentiation MO1 but inhibited the differentiation of MO2 in vitro and commuted apoptosis the MCM cells. Our results found the mouse anti-IL-5 NAB aggravated DOX-induced cardiac injury and dysfunction by reducing the inflammatory response and myocardial cell apoptosis.

This article is protected by copyright. All rights reserved. Asthma is a chronic inflammatory disorder is associated with high levels of cytokines such as interleukin-5 (IL-5), which plays an important role in the differentiation and maturation of eosinophils. Thus, blockage of IL-5 using mepalizumab has been considered a promising therapeutic approach for asthma.

Rabbit Anti-Human interleukin 13 receptor, alpha 2 (IL13RA2) IgG (aff pure)
AB-23040-A	Alpha Diagnostics	100ug	EUR 578.4

Canine Interleukin-1 alpha (IL-1a) ELISA Kit, 96 tests, Quantitative
10475	Alpha Diagnostics	1 Kit	EUR 927.6

Human interleukin 13 receptor, alpha 2 (IL13RA2) Control/blocking peptide
AB-23040-P	Alpha Diagnostics	100ug	EUR 196.8

Rat Monoclonal Anti-Mouse Interleukin-10 IgG
AB-11310	Alpha Diagnostics	100 ug	EUR 416.4

Rat Monoclonal Anti-Mouse Interleukin-2 IgG
AB-10510	Alpha Diagnostics	100 ug	EUR 416.4

Rat Monoclonal Anti-Mouse Interleukin-4 IgG
AB-10810	Alpha Diagnostics	100 ug	EUR 416.4

Mouse Monoclonal Anti-Human Interleukin-10 IgG
AB-11210	Alpha Diagnostics	100 ug	EUR 416.4

Mouse Monoclonal Anti-Human Interleukin-15 IgG
AB-11510	Alpha Diagnostics	100 ug	EUR 416.4

Rat Monoclonal Anti-Mouse Interleukin-12p40 IgG
AB-11410	Alpha Diagnostics	100 ug	EUR 416.4

Rat Monoclonal Anti-Mouse Interleukin-12p75 IgG
AB-20910	Alpha Diagnostics	100 ug	EUR 416.4

Mouse Monoclonal Anti-Human Interleukin-2 IgG
AB-10210	Alpha Diagnostics	100 ug	EUR 416.4

Mouse Monoclonal Anti-Human Interleukin-3 IgG
AB-10610	Alpha Diagnostics	100 ug	EUR 416.4

Mouse Monoclonal Anti-Human Interleukin-4 IgG
AB-10710	Alpha Diagnostics	100 ug	EUR 416.4

Mouse Monoclonal Anti-Human Interleukin-6 IgG
AB-10910	Alpha Diagnostics	100 ug	EUR 416.4

Mouse Monoclonal Anti-Human Interleukin-7 IgG
AB-11010	Alpha Diagnostics	100 ug	EUR 416.4

Mouse Monoclonal Anti-Human Interleukin-8 IgG
AB-11110	Alpha Diagnostics	100 ug	EUR 416.4

Rabbit Anti-Human Interleukin-1 receptor-like 1 (IL1RL1) IgG (aff pure)
AB-23064-A	Alpha Diagnostics	100ug	EUR 578.4

Rabbit Anti-Human Interleukin-1 receptor-like 1 (IL1RL1) IgG (aff pure)
AB-23065-A	Alpha Diagnostics	100ug	EUR 578.4

Rabbit Anti-Human Interleukin-1 receptor-like 1 (IL1RL1) IgG (aff pure)
AB-23066-A	Alpha Diagnostics	100ug	EUR 578.4

OPRB00195-100UG - Interleukin-1 alpha Protein
OPRB00195-100UG	Aviva Systems Biology	100ug	EUR 823

Rat Monoclonal Anti-Mouse Interleukin-2 receptor IgG
AB-10310	Alpha Diagnostics	100 ug	EUR 416.4

Mouse Monoclonal Anti-Human Interleukin-2 receptor IgG
AB-10410	Alpha Diagnostics	100 ug	EUR 416.4

Anti- Interleukin-1 Alpha ( IL-1 alpha) Mouse Antibody
GWB-96E082	GenWay Biotech	0.05 mg	Ask for price

GOAT ANTI RAT INTERLEUKIN-1 ALPHA
MBS221291-01mg	MyBiosource	0.1mg	EUR 660

GOAT ANTI RAT INTERLEUKIN-1 ALPHA
MBS221291-5x01mg	MyBiosource	5x0.1mg	EUR 2795

RABBIT ANTI PIG INTERLEUKIN-1 ALPHA
MBS225890-01mg	MyBiosource	0.1mg	EUR 645

RABBIT ANTI PIG INTERLEUKIN-1 ALPHA
MBS225890-5x01mg	MyBiosource	5x0.1mg	EUR 2730

Goat anti Rabbit Interleukin-1 Alpha
MBS225351-01mg	MyBiosource	0.1mg	EUR 645

Goat anti Rabbit Interleukin-1 Alpha
MBS225351-5x01mg	MyBiosource	5x0.1mg	EUR 2730

RABBIT ANTI MOUSE INTERLEUKIN-1 ALPHA
MBS221261-01mg	MyBiosource	0.1mg	EUR 635

RABBIT ANTI MOUSE INTERLEUKIN-1 ALPHA
MBS221261-5x01mg	MyBiosource	5x0.1mg	EUR 2695

Rabbit anti Bovine Interleukin-1 Alpha
MBS225002-01mg	MyBiosource	0.1mg	EUR 645

Rabbit anti Bovine Interleukin-1 Alpha
MBS225002-5x01mg	MyBiosource	5x0.1mg	EUR 2730

Interleukin 1 alpha, Recombinant, Mouse (Interleukin-1 alpha, IL-1 alpha, IL-1a, IL1A)
MBS637481-001mg	MyBiosource	0.01mg	EUR 445

Interleukin 1 alpha, Recombinant, Mouse (Interleukin-1 alpha, IL-1 alpha, IL-1a, IL1A)
MBS637481-005mg	MyBiosource	0.05mg	EUR 1000

Interleukin 1 alpha, Recombinant, Mouse (Interleukin-1 alpha, IL-1 alpha, IL-1a, IL1A)
MBS637481-5x005mg	MyBiosource	5x0.05mg	EUR 4350

Il1a (untagged) - Mouse interleukin 1 alpha (cDNA clone MGC:5780 IMAGE:3599550), (10ug)
MC206467	Origene Technologies GmbH	10 µg	Ask for price

Interleukin-1 alpha
AP78355	SAB	1mg	EUR 2640

Interleukin-1 alpha
AP78356	SAB	1mg	EUR 2640

Interleukin-1 alpha
AP84142	SAB	1mg	EUR 2640

Interleukin-1 alpha
AP84515	SAB	1mg	EUR 2640

Interleukin-1 alpha
AP84586	SAB	1mg	EUR 2640

Interleukin-1 alpha
AP84665	SAB	1mg	EUR 2640

Anti- Interleukin-1 Alpha ( IL-1alpha) Antibody
GWB-837A98	GenWay Biotech	0.05 mg	Ask for price

RABBIT ANTI PIG INTERLEUKIN-1 ALPHA: Biotin
MBS225891-005mg	MyBiosource	0.05mg	EUR 645

RABBIT ANTI PIG INTERLEUKIN-1 ALPHA: Biotin
MBS225891-5x005mg	MyBiosource	5x0.05mg	EUR 2730

Goat anti Rabbit Interleukin-1 Alpha: Biotin
MBS225352-005mg	MyBiosource	0.05mg	EUR 645

Goat anti Rabbit Interleukin-1 Alpha: Biotin
MBS225352-5x005mg	MyBiosource	5x0.05mg	EUR 2730

Interleukin-1 Alpha Antibody
GWB-6CB29D	GenWay Biotech	0.1 mg	Ask for price

Rabbit Anti-Human Interleukin 6 receptor (IL-6RCD126, gp80/IL-6RA)
AB-22124	Alpha Diagnostics	50 ul	EUR 562.8

Pig Interleukin-1 beta (IL-1?) ELISA Kit, 96 tests, Quantitative
10415	Alpha Diagnostics	1 Kit	EUR 927.6

Rabbit anti Bovine Interleukin-1 Alpha: Biotin
MBS225003-005mg	MyBiosource	0.05mg	EUR 645

Rabbit anti Bovine Interleukin-1 Alpha: Biotin
MBS225003-5x005mg	MyBiosource	5x0.05mg	EUR 2730

Rat Interleukin-1 alpha (IL-1 alpha) Antibody
32524-05111	AssayPro	150 ug	EUR 215

IL-1 alpha, Interleukin-1 alpha, rat
RC252-12A	Bio Basic	2ug	EUR 125.26

Human Interleukin-1 alpha (IL-1 alpha) Antibody
32196-05111	AssayPro	150 ug	EUR 215

Human Interleukin-1 receptor-like 1 (IL1RL1) Control/blocking peptide
AB-23064-P	Alpha Diagnostics	100ug	EUR 196.8

Human Interleukin-1 receptor-like 1 (IL1RL1) Control/blocking peptide
AB-23065-P	Alpha Diagnostics	100ug	EUR 196.8

Human Interleukin-1 receptor-like 1 (IL1RL1) Control/blocking peptide
AB-23066-P	Alpha Diagnostics	100ug	EUR 196.8

IL-1 alpha, Interleukin-1 alpha, human
RC212-12A	Bio Basic	2ug	EUR 125.26

Mouse interleukin 1 alpha
MBS400091-001mg	MyBiosource	0.01mg	EUR 220

Mouse interleukin 1 alpha
MBS400091-005mg	MyBiosource	0.05mg	EUR 545

Mouse interleukin 1 alpha
MBS400091-01mg	MyBiosource	0.1mg	EUR 770

Mouse interleukin 1 alpha
MBS400091-1mg	MyBiosource	1mg	EUR 2895

Interleukin 1 Alpha (IL1A) Antibody
abx001782-100l	Abbexa	100 µl	EUR 400

Interleukin 1 Alpha (IL1A) Antibody
20-abx001782	Abbexa	Ask for price Ask for price Ask for price Ask for price	20 ul 50 ul 100 ul 200 ul

Interleukin 1 Alpha (IL1A) Antibody
abx001782-20l	Abbexa	20 µl	EUR 175

Interleukin 1 Alpha (IL1A) Antibody
abx001782-50l	Abbexa	50 µl	EUR 275

Interleukin 1 Alpha (IL1A) Antibody
abx033027-400l	Abbexa	400 µl	EUR 518.75

Interleukin 1 Alpha (IL1A) Antibody
abx033027-400ul	Abbexa	400 ul	EUR 627.6

Interleukin 1 Alpha (IL1A) Antibody
abx033027-80l	Abbexa	80 µl	EUR 281.25

Interleukin 1 Alpha (IL1A) Antibody
abx036412-100g	Abbexa	100 µg	EUR 337.5

Interleukin 1 Alpha (IL1A) Antibody
abx036412-100ug	Abbexa	100 ug	EUR 469.2

Interleukin 1 Alpha (IL1A) Antibody
abx018000-100ug	Abbexa	100 ug	EUR 460.8

Interleukin 1 Alpha (IL1A) Antibody
abx018000-1mg	Abbexa	1 mg	EUR 300

Interleukin 1 Alpha (IL1A) Antibody
abx011004-100g	Abbexa	100 µg	Ask for price

Interleukin 1 Alpha (IL1A) Antibody
abx011004-100ul	Abbexa	100 ul	EUR 493.2

Interleukin 1 Alpha (IL1A) Antibody
abx011004-10g	Abbexa	10 µg	EUR 362.5

Interleukin 1 Alpha (IL1A) Antibody
abx011004-200g	Abbexa	200 µg	Ask for price

Interleukin 1 Alpha (IL1A) Antibody
abx300512-100g	Abbexa	100 µg	EUR 362.5

Interleukin 1 Alpha (IL1A) Antibody
20-abx300512	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	20 ug 50 ug 100 ug 200 ug 1 mg

Interleukin 1 Alpha (IL1A) Antibody
abx300512-20g	Abbexa	20 µg	EUR 162.5

Interleukin 1 Alpha (IL1A) Antibody
abx300512-50g	Abbexa	50 µg	EUR 250

Interleukin 1 Alpha (IL1A) Antibody
abx109930-100l	Abbexa	100 µl	EUR 162.5

Interleukin 1 Alpha (IL1A) Antibody
20-abx109930	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	20 ug 50 ug 100 ug 200 ug 1 mg

Interleukin 1 Alpha (IL1A) Antibody
abx113230-100l	Abbexa	100 µl	EUR 612.5

Interleukin 1 Alpha (IL1A) Antibody
20-abx113230	Abbexa	Ask for price Ask for price	50 ul 150 ul

Interleukin 1 Alpha (IL1a) Antibody
abx131946-100g	Abbexa	100 µg	EUR 875

Interleukin 1 Alpha (IL1a) Antibody
20-abx131946	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	20 ug 50 ug 100 ug 200 ug 1 mg

Interleukin 1 Alpha (IL1a) Antibody
abx131946-20g	Abbexa	20 µg	EUR 375

Interleukin 1 Alpha (IL1a) Antibody
abx131946-5g	Abbexa	5 µg	EUR 300

Interleukin 1 Alpha (IL1a) Antibody
abx131947-100g	Abbexa	100 µg	EUR 712.5

Interleukin 1 Alpha (IL1a) Antibody
20-abx131947	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	20 ug 50 ug 100 ug 200 ug 1 mg

Interleukin 1 Alpha (IL1a) Antibody
abx131947-20g	Abbexa	20 µg	EUR 325

Interleukin 1 Alpha (IL1a) Antibody
abx131947-5g	Abbexa	5 µg	EUR 262.5

Interleukin 1 Alpha (IL1a) Antibody
abx131948-100g	Abbexa	100 µg	EUR 625

Interleukin 1 Alpha (IL1a) Antibody
20-abx131948	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	20 ug 50 ug 100 ug 200 ug 1 mg

Interleukin 1 Alpha (IL1a) Antibody
abx131948-20g	Abbexa	20 µg	EUR 300

Interleukin 1 Alpha (IL1a) Antibody
abx131948-5g	Abbexa	5 µg	EUR 237.5

Interleukin 1 Alpha (IL1A) Antibody
abx131949-100g	Abbexa	100 µg	EUR 875

Interleukin 1 Alpha (IL1A) Antibody
20-abx131949	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	20 ug 50 ug 100 ug 200 ug 1 mg

Interleukin 1 Alpha (IL1A) Antibody
abx131949-20g	Abbexa	20 µg	EUR 375

Interleukin 1 Alpha (IL1A) Antibody
abx131949-5g	Abbexa	5 µg	EUR 300

Interleukin 1 Alpha (IL1A) Antibody
abx131950-05mg	Abbexa	0.5 mg	EUR 375

Interleukin 1 Alpha (IL1A) Antibody
abx131950-100g	Abbexa	100 µg	EUR 300

Interleukin 1 Alpha (IL1A) Antibody
20-abx131950	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	20 ug 50 ug 100 ug 200 ug 1 mg

Interleukin 1 Alpha (IL1A) Antibody
abx131951-100mg	Abbexa	100 mg	EUR 812.5

Interleukin 1 Alpha (IL1A) Antibody
abx131951-10mg	Abbexa	10 mg	EUR 362.5

Interleukin 1 Alpha (IL1A) Antibody
20-abx131951	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	20 ug 50 ug 100 ug 200 ug 1 mg

Interleukin 1 Alpha (IL1a) Antibody
abx132312-01mg	Abbexa	0.1 mg	EUR 262.5

Interleukin 1 Alpha (IL1a) Antibody
20-abx132312	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	20 ug 50 ug 100 ug 200 ug 1 mg

Interleukin 1 Alpha (IL1a) Antibody
abx129396-100l	Abbexa	100 µl	EUR 262.5

Interleukin 1 Alpha (IL1a) Antibody
20-abx129396	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	10 ug 50 ug 100 ug 200 ug 1 mg

Interleukin 1 Alpha (IL1a) Antibody
abx129396-1ml	Abbexa	1 ml	EUR 687.5

Interleukin 1 Alpha (IL1a) Antibody
abx129396-200l	Abbexa	200 µl	EUR 325

Interleukin 1 Alpha (IL1a) Antibody
abx129503-100l	Abbexa	100 µl	EUR 262.5

Interleukin 1 Alpha (IL1a) Antibody
20-abx129503	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	10 ug 50 ug 100 ug 200 ug 1 mg

Interleukin 1 Alpha (IL1a) Antibody
abx129503-1ml	Abbexa	1 ml	EUR 687.5

Interleukin 1 Alpha (IL1a) Antibody
abx129503-200l	Abbexa	200 µl	EUR 325

Interleukin 1 Alpha (IL1A) Antibody
abx210848-100l	Abbexa	100 µl	EUR 350

Interleukin 1 Alpha (IL1A) Antibody
20-abx210848	Abbexa	Ask for price Ask for price	50 ul 100 ul

Interleukin 1 Alpha (IL1A) Antibody
abx210848-50l	Abbexa	50 µl	EUR 250

Interleukin 1 Alpha (IL1a) Antibody
abx173020-100l	Abbexa	100 µl	EUR 812.5

Interleukin 1 Alpha (IL1a) Antibody
20-abx173020	Abbexa	Ask for price Ask for price	200 ug 1 mg

Interleukin 1 Alpha (IL1a) Antibody
abx173020-1ml	Abbexa	1 ml	Ask for price

Interleukin 1 Alpha (IL1a) Antibody
abx173020-200l	Abbexa	200 µl	Ask for price

Interleukin 1 Alpha (IL1a) Antibody
abx173021-100l	Abbexa	100 µl	EUR 812.5

Interleukin 1 Alpha (IL1a) Antibody
20-abx173021	Abbexa	Ask for price Ask for price	200 ug 1 mg

Interleukin 1 Alpha (IL1a) Antibody
abx173021-1ml	Abbexa	1 ml	Ask for price

Interleukin 1 Alpha (IL1a) Antibody
abx173021-200l	Abbexa	200 µl	Ask for price

Interleukin 1 Alpha (IL1a) Antibody
abx173022-100l	Abbexa	100 µl	EUR 850

Interleukin 1 Alpha (IL1a) Antibody
20-abx173022	Abbexa	Ask for price Ask for price	200 ug 1 mg

Interleukin 1 Alpha (IL1a) Antibody
abx173022-1ml	Abbexa	1 ml	Ask for price

Interleukin 1 Alpha (IL1a) Antibody
abx173022-200l	Abbexa	200 µl	Ask for price

Interleukin 1 Alpha (IL1a) Antibody
abx173023-100l	Abbexa	100 µl	EUR 850

Interleukin 1 Alpha (IL1a) Antibody
20-abx173023	Abbexa	Ask for price Ask for price	200 ug 1 mg

Interleukin 1 Alpha (IL1a) Antibody
abx173023-1ml	Abbexa	1 ml	Ask for price

Interleukin 1 Alpha (IL1a) Antibody
abx173023-200l	Abbexa	200 µl	Ask for price

Interleukin 1 Alpha (IL1a) Antibody
20-abx173024	Abbexa	Ask for price Ask for price	200 ug 1 mg

Interleukin 1 Alpha (IL1a) Antibody
20-abx177052	Abbexa	Ask for price Ask for price	200 ug 1 mg

Interleukin 1 Alpha (IL1a) Antibody
20-abx177054	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	10 ug 50 ug 100 ug 200 ug 1 mg

Interleukin 1 Alpha (IL1a) Antibody
abx177054-1096tests	Abbexa	10 × 96 tests	EUR 812.5

Interleukin 1 Alpha (IL1a) Antibody
abx177054-596tests	Abbexa	5 × 96 tests	EUR 362.5

Interleukin 1 Alpha (IL1a) Antibody
abx177054-96tests	Abbexa	96 tests	EUR 287.5

Interleukin 1 Alpha (IL1a) Antibody
20-abx177055	Abbexa	Ask for price Ask for price	200 ug 1 mg

Interleukin 1 Alpha (IL1A) Antibody
abx211106-100l	Abbexa	100 µl	EUR 350

Interleukin 1 Alpha (IL1A) Antibody
20-abx211106	Abbexa	Ask for price Ask for price	50 ul 100 ul

Interleukin 1 Alpha (IL1A) Antibody
abx211106-50l	Abbexa	50 µl	EUR 250

Interleukin 1 Alpha (IL1a) Antibody
abx128132-100l	Abbexa	100 µl	EUR 250

Interleukin 1 Alpha (IL1a) Antibody
20-abx128132	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	10 ug 50 ug 100 ug 200 ug 1 mg

Interleukin 1 Alpha (IL1a) Antibody
abx128132-1ml	Abbexa	1 ml	EUR 675

Interleukin 1 Alpha (IL1a) Antibody
abx128132-200l	Abbexa	200 µl	EUR 312.5

Interleukin 1 Alpha (IL1a) Antibody
abx104904-100g	Abbexa	100 µg	EUR 775

Interleukin 1 Alpha (IL1a) Antibody
20-abx104904	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	10 ug 50 ug 100 ug 200 ug 1 mg

Despite the advantages of antibodies monocolonal, some restrictions provide the background is accepted for alternative agents such as aptamers that can replace the antibodies. In the current study, aptamer isolation of the IL-5 molecule was intended, according to the valuable benefits of aptamers more antibodies.