Ghrelin is a peptide hormone with a direct or indirect effect on obesity and asthma. More data is needed to understand the effects of ghrelin on the control and pathogenesis of this disease. The purpose of this study was to evaluate the level of ghrelin in selected groups of children to identify the relationship between serum ghrelin, obesity and asthma severity. The study involved 401 school children were selected from the region of Najran and grouped into non-obese people with asthma, obese patients with asthma, obese non-asthmatics and controls (non-obese non-asthmatics). levels of ghrelin, interleukin (IL) -4, IL-5 and IL-21 were determined by ELISA.

The mean value of ghrelin were not significantly elevated in obese children compared with children of non-obese. The highest blood ghrelin values ​​are in the non-obese asthma group. Serum ghrelin, IL-4 and IL-21 levels were significantly increased in children with asthma compared with children of non-asthma (p <0.05), and there was a significant positive correlation between ghrelin and IL-4, IL -5, and IL-21 in children with asthma.

Furthermore, ghrelin, the level of IL-4 and IL-21 were significantly higher in patients with uncontrolled asthma compared to controlled-asthmatic children (p <0.05). Asthma is a significant risk factor only for values ​​higher ghrelin. This study provides evidence that supports the anti-inflammatory role of ghrelin in the pathogenesis of asthma. Asthma may be considered as an important determinant of the values ​​of ghrelin were higher in children.

Serum Ghrelin Levels in Saudi Obese Asthmatic School-Children-Correlation with <em>Interleukin</em>-4, <em>Interleukin</em>-<em>5</em>, and <em>Interleukin</em>-21.
Serum Ghrelin Levels in Saudi Obese Asthmatic School-Children-Correlation with Interleukin-4, Interleukin5, and Interleukin-21.

Anti interleukin – 5 -neutralizing antibody attenuates cardiac injury and cardiac dysfunction by aggravating the inflammatory response in the doxorubicin-treated mice.

Previous studies have shown that interleukin (ILS) are closely associated with doxorubicin (DOX) -induced cardiac injury. IL-5 is an important member of the family IL, and the study was conducted to investigate whether IL-5 affect DOX-induced cardiac injury and the underlying mechanisms. The heart of the IL-5 expression was first detected and the results showed that the heart of IL-5 levels were significantly lowered in DOX-treated mice, and IL-5 is mainly derived from the heart mo.

In addition, some mice DOX-treated received injections of antibodies anti-IL-5-neutralizing (NAB), and we found that treatment with mouse anti-IL-5 NAB significantly up-regulated levels of markers of myocardial injury, exacerbated cardiac dysfunction, increased M1 macrophages (mO1) and a decrease in M2 macrophages (MO2) differentiation, and promoted the expression of markers of apoptosis.

In addition, the effect of mouse IL-5 TLV on differentiation mo DOX-induced and its role in cardiomyocyte rat (MCM) of apoptotic cells detected in vitro, and the results exhibited that the mouse IL-5 NAB promoted differentiation MO1 but inhibited the differentiation of MO2 in vitro and commuted apoptosis the MCM cells. Our results found the mouse anti-IL-5 NAB aggravated DOX-induced cardiac injury and dysfunction by reducing the inflammatory response and myocardial cell apoptosis.

This article is protected by copyright. All rights reserved. Asthma is a chronic inflammatory disorder is associated with high levels of cytokines such as interleukin-5 (IL-5), which plays an important role in the differentiation and maturation of eosinophils. Thus, blockage of IL-5 using mepalizumab has been considered a promising therapeutic approach for asthma.

IL-1-alpha Interleukin-1 alpha Human Recombinant Protein, His Tag

PROTP01583-1 Regular: 20ug
EUR 317
Description: IL-1A Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 159 amino acids fragment (113-271) with an amino-terminal hexahistidine tag and having a total molecular mass of 22.5kDa. ;The Interleukin-1 alpha His-tag is purified by proprietary chromatographic techniques.

IL-1-alpha Interleukin-1 alpha Rat Recombinant Protein, His Tag

PROTP16598-1 Regular: 20ug
EUR 317
Description: IL 1 alpha Rat Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 179 amino acids (115-270 a.a) and having a molecular mass of 20.2kDa.

Anti-IL6/ Interleukin 6 Antibody Clone IL6-Q3, Unconjugated-100ug

QDX34-100ug 100ug
EUR 403

Anti-IL6/ Interleukin 6 Antibody Clone IL6-Q2, Unconjugated-100ug

QDX35-100ug 100ug
EUR 403

Anti-IL6/ Interleukin 6 Antibody Clone IL6-Q1, Unconjugated-100ug

QDX36-100ug 100ug
EUR 403

Anti-IL6/ Interleukin 6 Antibody Clone IL6-Q8, Unconjugated-100ug

QDX37-100ug 100ug
EUR 403

Recombinant purified, human Interleukin-1 alpha (IL-1 alpha), active

IL1A15-R-10 10 ug
EUR 347

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 349

Anti-CD86 Antibody [GL-1], Unconjugated-100ug

QAB51-100ug 100ug
EUR 157

Anti-FCER1A Antibody [MAR-1], Unconjugated-100ug

QAB91-100ug 100ug
EUR 182

Interleukin 13 Receptor Alpha 1 (IL13RA1) Antibody

abx036484-100ug 100 ug
EUR 391

Interleukin 13 Receptor Alpha 1 (IL13RA1) Antibody

abx019115-100ug 100 ug
EUR 342

Anti-CD54/ ICAM-1 Antibody [15.2], Unconjugated-100ug

QAB47-100ug 100ug
EUR 157

Anti-CD279/ PD-1 Antibody [J43.1], Unconjugated-100ug

QAB98-100ug 100ug
EUR 200

Anti-CD86 Antibody [GL-1], APC-100ug

QAB51-APC-100ug 100ug
EUR 276

Anti-CD86 Antibody [GL-1], FITC-100ug

QAB51-F-100ug 100ug
EUR 191

Anti-CD86 Antibody [GL-1], PE-100ug

QAB51-PE-100ug 100ug
EUR 225

Anti-LPAM-1 Antibody [DATK32], APC-100ug

QAB73-APC-100ug 100ug
EUR 276

Anti-LPAM-1 Antibody [DATK32], Biotin-100ug

QAB73-B-100ug 100ug
EUR 157

Anti-LPAM-1 Antibody [DATK32], PE-100ug

QAB73-PE-100ug 100ug
EUR 233

Anti-FCER1A Antibody [MAR-1], FITC-100ug

QAB91-F-100ug 100ug
EUR 200

Anti-FCER1A Antibody [MAR-1], PE-100ug

QAB91-PE-100ug 100ug
EUR 200

Interleukin 22 Receptor Subunit Alpha 1 (IL22RA1) Antibody

abx234253-100ug 100 ug
EUR 481

Anti-Integrin alpha 1/ITGA1 Antibody

PA1045-1 100ug/vial
EUR 334

Anti-HIF-1 alpha/HIF1A Antibody

A00013-1 100ug/vial
EUR 294

Anti-CD178/ Fas ligand Antibody [NOK-1], Unconjugated-100ug

QAB85-100ug 100ug
EUR 200

Recombinant Human IL-1 alpha/ IL1A/ IL1F1 Protein, Untagged, E.coli-100ug

QP5298-100ug 100ug
EUR 708

Recombinant Human IL6/ Interleukin 6 Protein, Native, Human-100ug

QDX53-100ug 100ug
EUR 615

Recombinant Human IL7/ Interleukin 7 Protein, Untagged, E.coli-100ug

QP1180-100ug 100ug
EUR 708

Recombinant Mouse IL6/ Interleukin-6 Protein, Untagged, E.coli-100ug

QP1487-100ug 100ug
EUR 608

Recombinant Human IL6/ Interleukin-6 Protein, Untagged, E.coli-100ug

QP5235-100ug 100ug
EUR 490

Recombinant Mouse IL7/ Interleukin 7 Protein, Untagged, E.coli-100ug

QP5401-100ug 100ug
EUR 708

Recombinant Mouse IL19/ Interleukin-19 Protein, Untagged, E.coli-100ug

QP5483-100ug 100ug
EUR 237

Recombinant Rat IL6/ Interleukin-6 Protein, Untagged, E.coli-100ug

QP5501-100ug 100ug
EUR 708

Anti-CD86 Antibody [GL-1], PE-Cy7-100ug

QAB51-PE7-100ug 100ug
EUR 377

Anti-CD86 Antibody [GL-1], Qfluor 630-100ug

QAB51-QF630-100ug 100ug
EUR 233

Anti-CD357/ GITR Antibody [DTA-1], APC-100ug

QAB72-APC-100ug 100ug
EUR 310

Anti-CD357/ GITR Antibody [DTA-1], FITC-100ug

QAB72-F-100ug 100ug
EUR 251

Anti-CD357/ GITR Antibody [DTA-1], PE-100ug

QAB72-PE-100ug 100ug
EUR 293

Anti-FCER1A Antibody [MAR-1], Qfluor 630-100ug

QAB91-QF630-100ug 100ug
EUR 251

Anti-CD279/ PD-1 Antibody [J43.1], PE-100ug

QAB98-PE-100ug 100ug
EUR 251

Recombinant Human Interleukin-26 Protein, His, Yeast-100ug

QP9904-ye-100ug 100ug
EUR 480

Recombinant Sheep Interleukin-8 Protein, His, E.coli-100ug

QP6228-ec-100ug 100ug
EUR 707

Anti-TCP-1α Monoclonal Antibody (91a)

M02389-1 200ug
EUR 498
Description: Rat Monoclonal TCP-1α Antibody (91a). Validated in Flow Cytometry, IP, IF, WB and tested in Human, Mouse, Rat.

Recombinant Human HIF-1 alpha/ HIF1A Protein, His, E.coli-100ug

QP1121-ec-100ug 100ug
EUR 408

Recombinant S. cerevisiae Alpha-galactosidase 1 Protein, His, Yeast-100ug

QP7286-ye-100ug 100ug
EUR 788

Recombinant Human Interferon alpha-inducible protein 1, His, Yeast-100ug

QP9195-ye-100ug 100ug
EUR 480

Anti-CD314 Antibody [CX5], Unconjugated-100ug

QAB100-100ug 100ug
EUR 182

Anti-CD4 Antibody [OKT4], Unconjugated-100ug

QAB11-100ug 100ug
EUR 123

Anti-CD8a Antibody [Hit8a], Unconjugated-100ug

QAB20-100ug 100ug
EUR 149

Anti-CD11c Antibody [N418], Unconjugated-100ug

QAB23-100ug 100ug
EUR 157

Anti-CD11c Antibody [3.9], Unconjugated-100ug

QAB24-100ug 100ug
EUR 141

Anti-CD11b Antibody [ICRF44], Unconjugated-100ug

QAB25-100ug 100ug
EUR 141

Anti-CD19 Antibody [1D3], Unconjugated-100ug

QAB28-100ug 100ug
EUR 141

Anti-CD3 Antibody [17A2], Unconjugated-100ug

QAB3-100ug 100ug
EUR 141

Anti-CD25 Antibody [PC61.5], Unconjugated-100ug

QAB34-100ug 100ug
EUR 123

Anti-CD25 Antibody [BC96], Unconjugated-100ug

QAB35-100ug 100ug
EUR 141

Anti-CD27 Antibody [O323], Unconjugated-100ug

QAB36-100ug 100ug
EUR 141

Anti-CD28 Antibody [CD28.2], Unconjugated-100ug

QAB37-100ug 100ug
EUR 141

Anti-CD45.1 Antibody [A20], Unconjugated-100ug

QAB42-100ug 100ug
EUR 157

Anti-CD45.2 Antibody [104], Unconjugated-100ug

QAB43-100ug 100ug
EUR 141

Anti-CD45RO Antibody [UCHL1], Unconjugated-100ug

QAB44-100ug 100ug
EUR 141

Anti-CD45RA Antibody [HI100], Unconjugated-100ug

QAB45-100ug 100ug
EUR 141

Anti-CD45 Antibody [HI30], Unconjugated-100ug

QAB46-100ug 100ug
EUR 141

Anti-CD3 Antibody [OKT3], Unconjugated-100ug

QAB5-100ug 100ug
EUR 149

Anti-CD3 Antibody [UCHT1], Unconjugated-100ug

QAB6-100ug 100ug
EUR 141

Anti-CD8a Antibody [2.43], Unconjugated-100ug

QAB61-100ug 100ug
EUR 149

Anti-CD3 Antibody [Hit3a], Unconjugated-100ug

QAB7-100ug 100ug
EUR 141

Anti-KLRG1 Antibody [2F1], Unconjugated-100ug

QAB74-100ug 100ug
EUR 141

Anti-CD161 Antibody [PK136], Unconjugated-100ug

QAB78-100ug 100ug
EUR 141

Anti-CD4 Antibody [GK1.5], Unconjugated-100ug

QAB8-100ug 100ug
EUR 123

Anti-CD32 Antibody [2.4G2], Unconjugated-100ug

QAB87-100ug 100ug
EUR 141

Anti-CD28 Antibody [37.51], Unconjugated-100ug

QAB99-100ug 100ug
EUR 149

Recombinant Mouse Il27 alpha Protein, Untagged, E.coli-100ug

QP5457-100ug 100ug
EUR 708

Recombinant Rat Tnf alpha Protein, Untagged, E.coli-100ug

QP5508-100ug 100ug
EUR 490

Pig Interleukin-1 alpha (IL-1?) ELISA Kit, 96 tests, Quantitative

10410 1 Kit
EUR 773

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx149072-100ug 100 ug
EUR 425

Interleukin 11 Receptor Alpha (IL11RA) Antibody

abx036160-100ug 100 ug
EUR 391

Interleukin 27 Receptor Alpha (IL27RA) Antibody

abx036669-100ug 100 ug
EUR 391

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx015891-100ug 100 ug
EUR 411

Interleukin 3 Receptor Alpha (IL3RA) Antibody

abx015894-100ug 100 ug
EUR 411

Interleukin 10 Receptor Alpha (IL10RA) Antibody

abx234213-100ug 100 ug
EUR 551

Interleukin 11 Receptor Alpha (IL11RA) Antibody

abx234217-100ug 100 ug
EUR 481

Interleukin 3 Receptor Alpha (IL3RA) Antibody

abx234277-100ug 100 ug
EUR 551

Interleukin 5 Receptor Alpha (IL5RA) Antibody

abx234280-100ug 100 ug
EUR 481

IL-1 alpha, Interleukin-1 alpha, human

RC212-12A 2ug
EUR 104.38

IL-1 alpha, Interleukin-1 alpha, rat

RC252-12A 2ug
EUR 104.38

Recombinant Mouse Interleukin-2/ IL-2 Protein, Untagged, E.coli-100ug

QP1489-100ug 100ug
EUR 490

Recombinant Rat Interleukin-2/ IL-2 Protein, Untagged, E.coli-100ug

QP1546-100ug 100ug
EUR 599

Recombinant Human Interleukin-32/ IL-32 Protein, Untagged, E.coli-100ug

QP5209-100ug 100ug
EUR 708

Recombinant Human Interleukin-21/ IL-21 Protein, Untagged, E.coli-100ug

QP5394-100ug 100ug
EUR 708

Horse Interleukin 1 alpha (IL1a) ELISA Kit, 96 tests, Quantitative

10515 1 Kit
EUR 773

Anti-CD54/ ICAM-1 Antibody [15.2], Qfluor 630-100ug

QAB47-QF630-100ug 100ug
EUR 233

Anti-CD178/ Fas ligand Antibody [NOK-1], Biotin-100ug

QAB85-B-100ug 100ug
EUR 251

Anti-CD279/ PD-1 Antibody [J43.1], Qfluor 630-100ug

QAB98-QF630-100ug 100ug
EUR 276

Anti-AFP/Alpha 1 Fetoprotein Rabbit Monoclonal Antibody

M00522-1 100ug/vial
EUR 397
Description: Rabbit Monoclonal AFP/Alpha 1 Fetoprotein Antibody. Validated in IP, IF, WB and tested in Human.

Anti-SERPINA1/Alpha 1 Antitrypsin Rabbit Monoclonal Antibody

M00720-1 100ug/vial
EUR 397
Description: Rabbit Monoclonal SERPINA1/Alpha 1 Antitrypsin Antibody. Validated in IP, IF, WB and tested in Human.

Recombinant Human Collagen alpha-1(XV) chain Protein, Untagged, E.coli-100ug

QP10332-ec-100ug 100ug
EUR 290

Recombinant Chicken Collagen alpha-1(XII) chain Protein, His, E.coli-100ug

QP5851-ec-100ug 100ug
EUR 707

Recombinant Chicken Collagen alpha-1(XII) chain Protein, His, Yeast-100ug

QP5851-ye-100ug 100ug
EUR 788

Recombinant Mouse ENO1/ Enolase 1/ alpha-enolase Protein, His, E.coli-100ug

QP5984-ec-100ug 100ug
EUR 571

Recombinant Human Proteasome subunit alpha type-1 Protein, His, E.coli-100ug

QP6543-ec-100ug 100ug
EUR 408

Recombinant Human Collagen alpha-1(XII) chain Protein, His, E.coli-100ug

QP8023-ec-100ug 100ug
EUR 408

Recombinant Human ENO1/ Enolase 1/ alpha-enolase Protein, GST, E.coli-100ug

QP8407-ec-100ug 100ug
EUR 408

Recombinant Human Collagen alpha-1(IV) chain Protein, GST, E.coli-100ug

QP8716-ec-100ug 100ug
EUR 408

Recombinant Human Collagen alpha-1(XVIII) chain Protein, GST, E.coli-100ug

QP8749-ec-100ug 100ug
EUR 408

Recombinant Human Collagen alpha-1(XVIII) chain Protein, His, Yeast-100ug

QP8749-ye-100ug 100ug
EUR 480

Recombinant S. cerevisiae Alpha-galactosidase 1 Protein, His-SUMO, E.coli-100ug

QP7286-ec-100ug 100ug
EUR 707

Recombinant Human Collagen alpha-1(XVII) chain Protein, His, E.coli-100ug

QP8920-ec-100ug 100ug
EUR 408

Recombinant Human Collagen alpha-1(XI) chain Protein, GST, Yeast-100ug

QP9074-ye-100ug 100ug
EUR 670

Recombinant Rat Collagen alpha-1(I) chain Protein, His, Yeast-100ug

QP9077-ye-100ug 100ug
EUR 571

Recombinant Human Transcription intermediary factor 1-alpha Protein, His, Yeast-100ug

QP6842-ye-100ug 100ug
EUR 480

Recombinant Sheep IL10/ Interleukin-10 Protein, His, Yeast-100ug

QP9777-ye-100ug 100ug
EUR 788

Recombinant Human IL16/ Interleukin-16 Protein, Untagged, E.coli-100ug

QP10303-ec-100ug 100ug
EUR 1678

Recombinant Human IL2/ Interleukin-2 Protein, Untagged, E.coli-100ug

QP10309-ec-100ug 100ug
EUR 326

Recombinant Human IL4/ Interleukin-4 Protein, Untagged, E.coli-100ug

QP10311-ec-100ug 100ug
EUR 870

Recombinant Human IL10/ Interleukin-10 Protein, Untagged, E.coli-100ug

QP10318-ec-100ug 100ug
EUR 1678

Recombinant Human IL19/ Interleukin-19 Protein, Untagged, E.coli-100ug

QP10324-ec-100ug 100ug
EUR 1678

Recombinant Human IL20/ Interleukin-20 Protein, Untagged, E.coli-100ug

QP10325-ec-100ug 100ug
EUR 1678

Recombinant Human IL22/ Interleukin 22 Protein, Untagged, E.coli-100ug

QP10327-ec-100ug 100ug
EUR 1678

Recombinant Macaque IL4/ Interleukin-4 Protein, Untagged, E.coli-100ug

QP10337-ec-100ug 100ug
EUR 1024

Recombinant Macaque IL16/ Interleukin-16 Protein, Untagged, E.coli-100ug

QP10443-ec-100ug 100ug
EUR 1995

Recombinant Mouse IL4/ Interleukin-4 Protein, Untagged, E.coli-100ug

QP10453-ec-100ug 100ug
EUR 870

Recombinant Mouse IL10/ Interleukin-10 Protein, Untagged, E.coli-100ug

QP10458-ec-100ug 100ug
EUR 1678

Recombinant Mouse IL16/ Interleukin-16 Protein, Untagged, E.coli-100ug

QP10461-ec-100ug 100ug
EUR 1995

Recombinant Mouse IL21/ Interleukin 21 Protein, Untagged, E.coli-100ug

QP10462-ec-100ug 100ug
EUR 1678

Recombinant Mouse IL22/ Interleukin 22 Protein, Untagged, E.coli-100ug

QP10463-ec-100ug 100ug
EUR 1678

Recombinant Human IL2/ Interleukin-2 Protein, GST, E.coli-100ug

QP6216-ec-100ug 100ug
EUR 408

Recombinant Human IL2/ Interleukin-2 Protein, His, Yeast-100ug

QP6216-ye-100ug 100ug
EUR 480

Recombinant Rabbit IL2/ Interleukin-2 Protein, His, E.coli-100ug

QP6218-ec-100ug 100ug
EUR 707

Recombinant Dog IL4/ Interleukin-4 Protein, His, E.coli-100ug

QP6222-ec-100ug 100ug
EUR 707

Recombinant Human IL10/ Interleukin-10 Protein, GST, E.coli-100ug

QP8553-ec-100ug 100ug
EUR 408

Recombinant Human IL4/ Interleukin-4 Protein, His, E.coli-100ug

QP8557-ec-100ug 100ug
EUR 408

Recombinant Human IL4/ Interleukin-4 Protein, His, Yeast-100ug

QP8557-ye-100ug 100ug
EUR 480

Recombinant Bovine IL10/ Interleukin-10 Protein, His, Yeast-100ug

QP9204-ye-100ug 100ug
EUR 788

Recombinant Macaque IL10/ Interleukin-10 Protein, His, Yeast-100ug

QP9205-ye-100ug 100ug
EUR 788

Recombinant other Gliadin Alpha Wheat Protein, His, E.coli-100ug

QP11983-100ug 100ug
EUR 218

Recombinant Mouse CXCL1/ GRO-alpha Protein, Untagged, E.coli-100ug

QP1455-100ug 100ug
EUR 490

Recombinant Human Interferon alpha 2a Protein, Untagged, E.coli-100ug

QP5364-100ug 100ug
EUR 237

Recombinant E.coli Glutamate decarboxylase alpha Protein, His, E.coli-100ug

QP6947-100ug 100ug
EUR 771

Anti-Hif3 alpha Antibody

A03805-1 100ug
EUR 455
Description: Rabbit Polyclonal Hif3 alpha Antibody. Validated in WB and tested in Mouse.

Anti-c-Myc Antibody [9E10], Unconjugated-100ug

QAB102-100ug 100ug
EUR 216

Anti-CD4 Antibody [RPA-T4], Unconjugated-100ug

QAB12-100ug 100ug
EUR 123

Anti-CD8a Antibody [53-6.7], Unconjugated-100ug

QAB16-100ug 100ug
EUR 131

Anti-CD8a Antibody [RPA-T8], Unconjugated-100ug

QAB19-100ug 100ug
EUR 149

Anti-CD3e Antibody [145-2C11], Unconjugated-100ug

QAB2-100ug 100ug
EUR 123

Anti-CD45 Antibody [30-F11], Unconjugated-100ug

QAB40-100ug 100ug
EUR 149

Anti-CD80 Antibody [16-10A1], Unconjugated-100ug

QAB50-100ug 100ug
EUR 182

Anti-CD161 Antibody [HP-3G10], Unconjugated-100ug

QAB60-100ug 100ug
EUR 157

Anti-IL-4 Antibody [11B11], Unconjugated-100ug

QAB81-100ug 100ug
EUR 149

Rabbit Anti Human Interleukin-1 Alpha Polyclonal Antibody

CPBT-65373RH 0.1 mg
EUR 881

Despite the advantages of antibodies monocolonal, some restrictions provide the background is accepted for alternative agents such as aptamers that can replace the antibodies. In the current study, aptamer isolation of the IL-5 molecule was intended, according to the valuable benefits of aptamers more antibodies.