Ghrelin is a peptide hormone with a direct or indirect effect on obesity and asthma. More data is needed to understand the effects of ghrelin on the control and pathogenesis of this disease. The purpose of this study was to evaluate the level of ghrelin in selected groups of children to identify the relationship between serum ghrelin, obesity and asthma severity. The study involved 401 school children were selected from the region of Najran and grouped into non-obese people with asthma, obese patients with asthma, obese non-asthmatics and controls (non-obese non-asthmatics). levels of ghrelin, interleukin (IL) -4, IL-5 and IL-21 were determined by ELISA.

The mean value of ghrelin were not significantly elevated in obese children compared with children of non-obese. The highest blood ghrelin values ​​are in the non-obese asthma group. Serum ghrelin, IL-4 and IL-21 levels were significantly increased in children with asthma compared with children of non-asthma (p <0.05), and there was a significant positive correlation between ghrelin and IL-4, IL -5, and IL-21 in children with asthma.

Furthermore, ghrelin, the level of IL-4 and IL-21 were significantly higher in patients with uncontrolled asthma compared to controlled-asthmatic children (p <0.05). Asthma is a significant risk factor only for values ​​higher ghrelin. This study provides evidence that supports the anti-inflammatory role of ghrelin in the pathogenesis of asthma. Asthma may be considered as an important determinant of the values ​​of ghrelin were higher in children.

Serum Ghrelin Levels in Saudi Obese Asthmatic School-Children-Correlation with <em>Interleukin</em>-4, <em>Interleukin</em>-<em>5</em>, and <em>Interleukin</em>-21.
Serum Ghrelin Levels in Saudi Obese Asthmatic School-Children-Correlation with Interleukin-4, Interleukin5, and Interleukin-21.

Anti interleukin – 5 -neutralizing antibody attenuates cardiac injury and cardiac dysfunction by aggravating the inflammatory response in the doxorubicin-treated mice.

Previous studies have shown that interleukin (ILS) are closely associated with doxorubicin (DOX) -induced cardiac injury. IL-5 is an important member of the family IL, and the study was conducted to investigate whether IL-5 affect DOX-induced cardiac injury and the underlying mechanisms. The heart of the IL-5 expression was first detected and the results showed that the heart of IL-5 levels were significantly lowered in DOX-treated mice, and IL-5 is mainly derived from the heart mo.

In addition, some mice DOX-treated received injections of antibodies anti-IL-5-neutralizing (NAB), and we found that treatment with mouse anti-IL-5 NAB significantly up-regulated levels of markers of myocardial injury, exacerbated cardiac dysfunction, increased M1 macrophages (mO1) and a decrease in M2 macrophages (MO2) differentiation, and promoted the expression of markers of apoptosis.

In addition, the effect of mouse IL-5 TLV on differentiation mo DOX-induced and its role in cardiomyocyte rat (MCM) of apoptotic cells detected in vitro, and the results exhibited that the mouse IL-5 NAB promoted differentiation MO1 but inhibited the differentiation of MO2 in vitro and commuted apoptosis the MCM cells. Our results found the mouse anti-IL-5 NAB aggravated DOX-induced cardiac injury and dysfunction by reducing the inflammatory response and myocardial cell apoptosis.

This article is protected by copyright. All rights reserved. Asthma is a chronic inflammatory disorder is associated with high levels of cytokines such as interleukin-5 (IL-5), which plays an important role in the differentiation and maturation of eosinophils. Thus, blockage of IL-5 using mepalizumab has been considered a promising therapeutic approach for asthma.

Rat Monoclonal Anti-Mouse Interleukin-10 IgG

AB-11310 100 ug
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Rat Monoclonal Anti-Mouse Interleukin-4 IgG

AB-10810 100 ug
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Mouse Monoclonal Anti-Human Interleukin-2 IgG

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Interleukin-1 alpha

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32524-05111 150 ug
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RC252-12A 2ug
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32196-05111 150 ug
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Interleukin 1 Alpha (IL1A) Antibody

abx036412-100ug 100 ug
EUR 469.2

Interleukin 1 Alpha (IL1A) Antibody

abx033027-400ul 400 ul
EUR 627.6

Interleukin 1 Alpha (IL1A) Antibody

abx033027-80l 80 µl
EUR 343.2

Interleukin 1 Alpha (IL1A) Antibody

abx018000-100ug 100 ug
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Interleukin 1 Alpha (IL1A) Antibody

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Interleukin 1 Alpha (IL1A) Antibody

20-abx001782
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Interleukin 1 Alpha (IL1A) Antibody

abx001782-100l 100 µl
EUR 400

Interleukin 1 Alpha (IL1A) Antibody

abx001782-20l 20 µl
EUR 175

Interleukin 1 Alpha (IL1A) Antibody

abx001782-50l 50 µl
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Interleukin 1 Alpha (IL1A) Antibody

abx011004-100g 100 µg Ask for price

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abx011004-10g 10 µg
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Interleukin 1 Alpha (IL1A) Antibody

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Interleukin 1 Alpha (IL1a) Antibody

abx104904-100g 100 µg
EUR 775

Interleukin 1 Alpha (IL1a) Antibody

abx104904-20g 20 µg
EUR 275

Interleukin 1 Alpha (IL1a) Antibody

abx104904-50g 50 µg
EUR 350

Interleukin 1 Alpha (IL1a) Antibody

abx101885-100l 100 µl
EUR 287.5

Interleukin 1 Alpha (IL1a) Antibody

abx101885-1ml 1 ml
EUR 825

Interleukin 1 Alpha (IL1a) Antibody

abx101885-200l 200 µl
EUR 362.5

Interleukin 1 Alpha (IL1a) Antibody

abx101886-100l 100 µl
EUR 212.5

Interleukin 1 Alpha (IL1a) Antibody

abx101886-1ml 1 ml
EUR 475

Interleukin 1 Alpha (IL1a) Antibody

abx101886-200l 200 µl
EUR 250

Interleukin 1 Alpha (IL1a) Antibody

abx101887-100l 100 µl
EUR 250

Interleukin 1 Alpha (IL1a) Antibody

abx101887-1ml 1 ml
EUR 675

Interleukin 1 Alpha (IL1a) Antibody

abx101887-200l 200 µl
EUR 312.5

Interleukin 1 Alpha (IL1A) Antibody

abx101888-100l 100 µl
EUR 262.5

Interleukin 1 Alpha (IL1A) Antibody

abx101888-1ml 1 ml
EUR 725

Interleukin 1 Alpha (IL1A) Antibody

abx101888-200l 200 µl
EUR 337.5

Interleukin 1 Alpha (IL1a) Antibody

abx101889-100l 100 µl
EUR 275

Interleukin 1 Alpha (IL1a) Antibody

abx101889-1ml 1 ml
EUR 775

Interleukin 1 Alpha (IL1a) Antibody

abx101889-200l 200 µl
EUR 350

Interleukin 1 Alpha (IL1a) Antibody

abx101890-100l 100 µl
EUR 275

Interleukin 1 Alpha (IL1a) Antibody

abx101890-1ml 1 ml
EUR 775

Interleukin 1 Alpha (IL1a) Antibody

abx101890-200l 200 µl
EUR 350

Interleukin 1 Alpha (IL1a) Antibody

abx101891-100l 100 µl
EUR 287.5

Interleukin 1 Alpha (IL1a) Antibody

abx101891-1ml 1 ml
EUR 812.5

Interleukin 1 Alpha (IL1a) Antibody

abx101891-200l 200 µl
EUR 362.5

Interleukin 1 Alpha (IL1a) Antibody

abx101892-100l 100 µl
EUR 287.5

Interleukin 1 Alpha (IL1a) Antibody

abx101892-1ml 1 ml
EUR 825

Interleukin 1 Alpha (IL1a) Antibody

abx101892-200l 200 µl
EUR 362.5

Interleukin 1 Alpha (IL1A) Antibody

abx109930-100l 100 µl
EUR 162.5

Interleukin 1 Alpha (IL1A) Antibody

abx113230-100l 100 µl
EUR 612.5

Interleukin 1 Alpha (IL1a) Antibody

abx128132-100l 100 µl
EUR 250

Interleukin 1 Alpha (IL1a) Antibody

abx128132-1ml 1 ml
EUR 675

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abx128132-200l 200 µl
EUR 312.5

Interleukin 1 Alpha (IL1a) Antibody

abx129396-100l 100 µl
EUR 262.5

Interleukin 1 Alpha (IL1a) Antibody

abx129396-1ml 1 ml
EUR 687.5

Interleukin 1 Alpha (IL1a) Antibody

abx129396-200l 200 µl
EUR 325

Interleukin 1 Alpha (IL1a) Antibody

abx129503-100l 100 µl
EUR 262.5

Interleukin 1 Alpha (IL1a) Antibody

abx129503-1ml 1 ml
EUR 687.5

Interleukin 1 Alpha (IL1a) Antibody

abx129503-200l 200 µl
EUR 325

Interleukin 1 Alpha (IL1a) Antibody

abx173020-100l 100 µl
EUR 812.5

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abx173020-1ml 1 ml Ask for price

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abx173020-200l 200 µl Ask for price

Interleukin 1 Alpha (IL1a) Antibody

abx173021-100l 100 µl
EUR 812.5

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abx173021-200l 200 µl Ask for price

Interleukin 1 Alpha (IL1a) Antibody

abx173022-100l 100 µl
EUR 850

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abx173023-100l 100 µl
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Interleukin 1 Alpha (IL1A) Antibody

abx210848-100l 100 µl
EUR 350

Interleukin 1 Alpha (IL1A) Antibody

abx210848-50l 50 µl
EUR 250

Interleukin 1 Alpha (IL1A) Antibody

abx211106-100l 100 µl
EUR 350

Interleukin 1 Alpha (IL1A) Antibody

abx211106-50l 50 µl
EUR 250

Interleukin 1 Alpha (IL1a) Antibody

abx177054-1096tests 10 × 96 tests
EUR 812.5

Interleukin 1 Alpha (IL1a) Antibody

abx177054-596tests 5 × 96 tests
EUR 362.5

Interleukin 1 Alpha (IL1a) Antibody

abx177054-96tests 96 tests
EUR 287.5

Interleukin 1 Alpha (IL1A) Antibody

abx036412-100g 100 µg
EUR 337.5

Interleukin 1 Alpha (IL1A) Antibody

abx033027-400l 400 µl
EUR 518.75

Interleukin 1 Alpha (IL1A) Antibody

abx018000-1mg 1 mg
EUR 300

Interleukin 1 Alpha (IL1A) Antibody

abx300512-100g 100 µg
EUR 362.5

Interleukin 1 Alpha (IL1A) Antibody

abx300512-20g 20 µg
EUR 162.5

Interleukin 1 Alpha (IL1A) Antibody

abx300512-50g 50 µg
EUR 250

Interleukin 1 Alpha (IL1a) Antibody

abx131946-100g 100 µg
EUR 875

Interleukin 1 Alpha (IL1a) Antibody

abx131946-20g 20 µg
EUR 375

Interleukin 1 Alpha (IL1a) Antibody

abx131946-5g 5 µg
EUR 300

Interleukin 1 Alpha (IL1a) Antibody

abx131947-100g 100 µg
EUR 712.5

Interleukin 1 Alpha (IL1a) Antibody

abx131947-20g 20 µg
EUR 325

Interleukin 1 Alpha (IL1a) Antibody

abx131947-5g 5 µg
EUR 262.5

Interleukin 1 Alpha (IL1a) Antibody

abx131948-100g 100 µg
EUR 625

Interleukin 1 Alpha (IL1a) Antibody

abx131948-20g 20 µg
EUR 300

Interleukin 1 Alpha (IL1a) Antibody

abx131948-5g 5 µg
EUR 237.5

Interleukin 1 Alpha (IL1A) Antibody

abx131949-100g 100 µg
EUR 875

Interleukin 1 Alpha (IL1A) Antibody

abx131949-20g 20 µg
EUR 375

Despite the advantages of antibodies monocolonal, some restrictions provide the background is accepted for alternative agents such as aptamers that can replace the antibodies. In the current study, aptamer isolation of the IL-5 molecule was intended, according to the valuable benefits of aptamers more antibodies.