Ghrelin is a peptide hormone with a direct or indirect effect on obesity and asthma. More data is needed to understand the effects of ghrelin on the control and pathogenesis of this disease. The purpose of this study was to evaluate the level of ghrelin in selected groups of children to identify the relationship between serum ghrelin, obesity and asthma severity. The study involved 401 school children were selected from the region of Najran and grouped into non-obese people with asthma, obese patients with asthma, obese non-asthmatics and controls (non-obese non-asthmatics). levels of ghrelin, interleukin (IL) -4, IL-5 and IL-21 were determined by ELISA.

The mean value of ghrelin were not significantly elevated in obese children compared with children of non-obese. The highest blood ghrelin values ​​are in the non-obese asthma group. Serum ghrelin, IL-4 and IL-21 levels were significantly increased in children with asthma compared with children of non-asthma (p <0.05), and there was a significant positive correlation between ghrelin and IL-4, IL -5, and IL-21 in children with asthma.

Furthermore, ghrelin, the level of IL-4 and IL-21 were significantly higher in patients with uncontrolled asthma compared to controlled-asthmatic children (p <0.05). Asthma is a significant risk factor only for values ​​higher ghrelin. This study provides evidence that supports the anti-inflammatory role of ghrelin in the pathogenesis of asthma. Asthma may be considered as an important determinant of the values ​​of ghrelin were higher in children.

Serum Ghrelin Levels in Saudi Obese Asthmatic School-Children-Correlation with <em>Interleukin</em>-4, <em>Interleukin</em>-<em>5</em>, and <em>Interleukin</em>-21.
Serum Ghrelin Levels in Saudi Obese Asthmatic School-Children-Correlation with Interleukin-4, Interleukin–5, and Interleukin-21.

Anti interleukin – 5 -neutralizing antibody attenuates cardiac injury and cardiac dysfunction by aggravating the inflammatory response in the doxorubicin-treated mice.

Previous studies have shown that interleukin (ILS) are closely associated with doxorubicin (DOX) -induced cardiac injury. IL-5 is an important member of the family IL, and the study was conducted to investigate whether IL-5 affect DOX-induced cardiac injury and the underlying mechanisms. The heart of the IL-5 expression was first detected and the results showed that the heart of IL-5 levels were significantly lowered in DOX-treated mice, and IL-5 is mainly derived from the heart mo.

In addition, some mice DOX-treated received injections of antibodies anti-IL-5-neutralizing (NAB), and we found that treatment with mouse anti-IL-5 NAB significantly up-regulated levels of markers of myocardial injury, exacerbated cardiac dysfunction, increased M1 macrophages (mO1) and a decrease in M2 macrophages (MO2) differentiation, and promoted the expression of markers of apoptosis.

In addition, the effect of mouse IL-5 TLV on differentiation mo DOX-induced and its role in cardiomyocyte rat (MCM) of apoptotic cells detected in vitro, and the results exhibited that the mouse IL-5 NAB promoted differentiation MO1 but inhibited the differentiation of MO2 in vitro and commuted apoptosis the MCM cells. Our results found the mouse anti-IL-5 NAB aggravated DOX-induced cardiac injury and dysfunction by reducing the inflammatory response and myocardial cell apoptosis.

This article is protected by copyright. All rights reserved. Asthma is a chronic inflammatory disorder is associated with high levels of cytokines such as interleukin-5 (IL-5), which plays an important role in the differentiation and maturation of eosinophils. Thus, blockage of IL-5 using mepalizumab has been considered a promising therapeutic approach for asthma.

IL-1-alpha Interleukin-1 alpha Human Recombinant Protein, His Tag
PROTP01583-1 Regular: 20ug
EUR 317
Description: IL-1A Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 159 amino acids fragment (113-271) with an amino-terminal hexahistidine tag and having a total molecular mass of 22.5kDa. ;The Interleukin-1 alpha His-tag is purified by proprietary chromatographic techniques.

IL-1-alpha Interleukin-1 alpha Rat Recombinant Protein, His Tag
PROTP16598-1 Regular: 20ug
EUR 317
Description: IL 1 alpha Rat Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 179 amino acids (115-270 a.a) and having a molecular mass of 20.2kDa.

Anti-IL6/ Interleukin 6 Antibody Clone IL6-Q3, Unconjugated-100ug
QDX34-100ug 100ug
EUR 403

Anti-IL6/ Interleukin 6 Antibody Clone IL6-Q2, Unconjugated-100ug
QDX35-100ug 100ug
EUR 403

Anti-IL6/ Interleukin 6 Antibody Clone IL6-Q1, Unconjugated-100ug
QDX36-100ug 100ug
EUR 403

Anti-IL6/ Interleukin 6 Antibody Clone IL6-Q8, Unconjugated-100ug
QDX37-100ug 100ug
EUR 403

Recombinant purified, human Interleukin-1 alpha (IL-1 alpha), active
IL1A15-R-10 10 ug
EUR 347

Rabbit Polyclonal antibody Anti-CRBN
Anti-CRBN 50 µg
EUR 349

Anti-CD86 Antibody [GL-1], Unconjugated-100ug
QAB51-100ug 100ug
EUR 157

Anti-FCER1A Antibody [MAR-1], Unconjugated-100ug
QAB91-100ug 100ug
EUR 182

Interleukin 13 Receptor Alpha 1 (IL13RA1) Antibody
abx036484-100ug 100 ug
EUR 391

Interleukin 13 Receptor Alpha 1 (IL13RA1) Antibody
abx019115-100ug 100 ug
EUR 342

Anti-CD54/ ICAM-1 Antibody [15.2], Unconjugated-100ug
QAB47-100ug 100ug
EUR 157

Anti-CD279/ PD-1 Antibody [J43.1], Unconjugated-100ug
QAB98-100ug 100ug
EUR 200

Anti-CD86 Antibody [GL-1], APC-100ug
QAB51-APC-100ug 100ug
EUR 276

Anti-CD86 Antibody [GL-1], FITC-100ug
QAB51-F-100ug 100ug
EUR 191

Anti-CD86 Antibody [GL-1], PE-100ug
QAB51-PE-100ug 100ug
EUR 225

Anti-LPAM-1 Antibody [DATK32], APC-100ug
QAB73-APC-100ug 100ug
EUR 276

Anti-LPAM-1 Antibody [DATK32], Biotin-100ug
QAB73-B-100ug 100ug
EUR 157

Anti-LPAM-1 Antibody [DATK32], PE-100ug
QAB73-PE-100ug 100ug
EUR 233

Anti-FCER1A Antibody [MAR-1], FITC-100ug
QAB91-F-100ug 100ug
EUR 200

Anti-FCER1A Antibody [MAR-1], PE-100ug
QAB91-PE-100ug 100ug
EUR 200

Interleukin 22 Receptor Subunit Alpha 1 (IL22RA1) Antibody
abx234253-100ug 100 ug
EUR 481

Anti-Integrin alpha 1/ITGA1 Antibody
PA1045-1 100ug/vial
EUR 334

Anti-HIF-1 alpha/HIF1A Antibody
A00013-1 100ug/vial
EUR 294

Anti-CD178/ Fas ligand Antibody [NOK-1], Unconjugated-100ug
QAB85-100ug 100ug
EUR 200

Recombinant Human IL-1 alpha/ IL1A/ IL1F1 Protein, Untagged, E.coli-100ug
QP5298-100ug 100ug
EUR 708

Recombinant Human IL6/ Interleukin 6 Protein, Native, Human-100ug
QDX53-100ug 100ug
EUR 615

Recombinant Human IL7/ Interleukin 7 Protein, Untagged, E.coli-100ug
QP1180-100ug 100ug
EUR 708

Recombinant Mouse IL6/ Interleukin-6 Protein, Untagged, E.coli-100ug
QP1487-100ug 100ug
EUR 608

Recombinant Human IL6/ Interleukin-6 Protein, Untagged, E.coli-100ug
QP5235-100ug 100ug
EUR 490

Recombinant Mouse IL7/ Interleukin 7 Protein, Untagged, E.coli-100ug
QP5401-100ug 100ug
EUR 708

Recombinant Mouse IL19/ Interleukin-19 Protein, Untagged, E.coli-100ug
QP5483-100ug 100ug
EUR 237

Recombinant Rat IL6/ Interleukin-6 Protein, Untagged, E.coli-100ug
QP5501-100ug 100ug
EUR 708

Anti-CD86 Antibody [GL-1], PE-Cy7-100ug
QAB51-PE7-100ug 100ug
EUR 377

Anti-CD86 Antibody [GL-1], Qfluor 630-100ug
QAB51-QF630-100ug 100ug
EUR 233

Anti-CD357/ GITR Antibody [DTA-1], APC-100ug
QAB72-APC-100ug 100ug
EUR 310

Anti-CD357/ GITR Antibody [DTA-1], FITC-100ug
QAB72-F-100ug 100ug
EUR 251

Anti-CD357/ GITR Antibody [DTA-1], PE-100ug
QAB72-PE-100ug 100ug
EUR 293

Anti-FCER1A Antibody [MAR-1], Qfluor 630-100ug
QAB91-QF630-100ug 100ug
EUR 251

Anti-CD279/ PD-1 Antibody [J43.1], PE-100ug
QAB98-PE-100ug 100ug
EUR 251

Recombinant Human Interleukin-26 Protein, His, Yeast-100ug
QP9904-ye-100ug 100ug
EUR 480

Recombinant Sheep Interleukin-8 Protein, His, E.coli-100ug
QP6228-ec-100ug 100ug
EUR 707

Anti-TCP-1α Monoclonal Antibody (91a)
M02389-1 200ug
EUR 498
Description: Rat Monoclonal TCP-1α Antibody (91a). Validated in Flow Cytometry, IP, IF, WB and tested in Human, Mouse, Rat.

Recombinant Human HIF-1 alpha/ HIF1A Protein, His, E.coli-100ug
QP1121-ec-100ug 100ug
EUR 408

Recombinant S. cerevisiae Alpha-galactosidase 1 Protein, His, Yeast-100ug
QP7286-ye-100ug 100ug
EUR 788

Recombinant Human Interferon alpha-inducible protein 1, His, Yeast-100ug
QP9195-ye-100ug 100ug
EUR 480

Anti-CD314 Antibody [CX5], Unconjugated-100ug
QAB100-100ug 100ug
EUR 182

Anti-CD4 Antibody [OKT4], Unconjugated-100ug
QAB11-100ug 100ug
EUR 123

Anti-CD8a Antibody [Hit8a], Unconjugated-100ug
QAB20-100ug 100ug
EUR 149

Anti-CD11c Antibody [N418], Unconjugated-100ug
QAB23-100ug 100ug
EUR 157

Anti-CD11c Antibody [3.9], Unconjugated-100ug
QAB24-100ug 100ug
EUR 141

Anti-CD11b Antibody [ICRF44], Unconjugated-100ug
QAB25-100ug 100ug
EUR 141

Anti-CD19 Antibody [1D3], Unconjugated-100ug
QAB28-100ug 100ug
EUR 141

Anti-CD3 Antibody [17A2], Unconjugated-100ug
QAB3-100ug 100ug
EUR 141

Anti-CD25 Antibody [PC61.5], Unconjugated-100ug
QAB34-100ug 100ug
EUR 123

Anti-CD25 Antibody [BC96], Unconjugated-100ug
QAB35-100ug 100ug
EUR 141

Anti-CD27 Antibody [O323], Unconjugated-100ug
QAB36-100ug 100ug
EUR 141

Anti-CD28 Antibody [CD28.2], Unconjugated-100ug
QAB37-100ug 100ug
EUR 141

Anti-CD45.1 Antibody [A20], Unconjugated-100ug
QAB42-100ug 100ug
EUR 157

Anti-CD45.2 Antibody [104], Unconjugated-100ug
QAB43-100ug 100ug
EUR 141

Anti-CD45RO Antibody [UCHL1], Unconjugated-100ug
QAB44-100ug 100ug
EUR 141

Anti-CD45RA Antibody [HI100], Unconjugated-100ug
QAB45-100ug 100ug
EUR 141

Anti-CD45 Antibody [HI30], Unconjugated-100ug
QAB46-100ug 100ug
EUR 141

Anti-CD3 Antibody [OKT3], Unconjugated-100ug
QAB5-100ug 100ug
EUR 149

Anti-CD3 Antibody [UCHT1], Unconjugated-100ug
QAB6-100ug 100ug
EUR 141

Anti-CD8a Antibody [2.43], Unconjugated-100ug
QAB61-100ug 100ug
EUR 149

Anti-CD3 Antibody [Hit3a], Unconjugated-100ug
QAB7-100ug 100ug
EUR 141

Anti-KLRG1 Antibody [2F1], Unconjugated-100ug
QAB74-100ug 100ug
EUR 141

Anti-CD161 Antibody [PK136], Unconjugated-100ug
QAB78-100ug 100ug
EUR 141

Anti-CD4 Antibody [GK1.5], Unconjugated-100ug
QAB8-100ug 100ug
EUR 123

Anti-CD32 Antibody [2.4G2], Unconjugated-100ug
QAB87-100ug 100ug
EUR 141

Anti-CD28 Antibody [37.51], Unconjugated-100ug
QAB99-100ug 100ug
EUR 149

Recombinant Mouse Il27 alpha Protein, Untagged, E.coli-100ug
QP5457-100ug 100ug
EUR 708

Recombinant Rat Tnf alpha Protein, Untagged, E.coli-100ug
QP5508-100ug 100ug
EUR 490

Pig Interleukin-1 alpha (IL-1?) ELISA Kit, 96 tests, Quantitative
10410 1 Kit
EUR 773

Interleukin 2 Receptor Alpha (IL2RA) Antibody
abx149072-100ug 100 ug
EUR 425

Interleukin 11 Receptor Alpha (IL11RA) Antibody
abx036160-100ug 100 ug
EUR 391

Interleukin 27 Receptor Alpha (IL27RA) Antibody
abx036669-100ug 100 ug
EUR 391

Interleukin 2 Receptor Alpha (IL2RA) Antibody
abx015891-100ug 100 ug
EUR 411

Interleukin 3 Receptor Alpha (IL3RA) Antibody
abx015894-100ug 100 ug
EUR 411

Interleukin 10 Receptor Alpha (IL10RA) Antibody
abx234213-100ug 100 ug
EUR 551

Interleukin 11 Receptor Alpha (IL11RA) Antibody
abx234217-100ug 100 ug
EUR 481

Interleukin 3 Receptor Alpha (IL3RA) Antibody
abx234277-100ug 100 ug
EUR 551

Interleukin 5 Receptor Alpha (IL5RA) Antibody
abx234280-100ug 100 ug
EUR 481

IL-1 alpha, Interleukin-1 alpha, human
RC212-12A 2ug
EUR 104.38

IL-1 alpha, Interleukin-1 alpha, rat
RC252-12A 2ug
EUR 104.38

Recombinant Mouse Interleukin-2/ IL-2 Protein, Untagged, E.coli-100ug
QP1489-100ug 100ug
EUR 490

Recombinant Rat Interleukin-2/ IL-2 Protein, Untagged, E.coli-100ug
QP1546-100ug 100ug
EUR 599

Recombinant Human Interleukin-32/ IL-32 Protein, Untagged, E.coli-100ug
QP5209-100ug 100ug
EUR 708

Recombinant Human Interleukin-21/ IL-21 Protein, Untagged, E.coli-100ug
QP5394-100ug 100ug
EUR 708

Horse Interleukin 1 alpha (IL1a) ELISA Kit, 96 tests, Quantitative
10515 1 Kit
EUR 773

Anti-CD54/ ICAM-1 Antibody [15.2], Qfluor 630-100ug
QAB47-QF630-100ug 100ug
EUR 233

Anti-CD178/ Fas ligand Antibody [NOK-1], Biotin-100ug
QAB85-B-100ug 100ug
EUR 251

Anti-CD279/ PD-1 Antibody [J43.1], Qfluor 630-100ug
QAB98-QF630-100ug 100ug
EUR 276

Anti-AFP/Alpha 1 Fetoprotein Rabbit Monoclonal Antibody
M00522-1 100ug/vial
EUR 397
Description: Rabbit Monoclonal AFP/Alpha 1 Fetoprotein Antibody. Validated in IP, IF, WB and tested in Human.

Anti-SERPINA1/Alpha 1 Antitrypsin Rabbit Monoclonal Antibody
M00720-1 100ug/vial
EUR 397
Description: Rabbit Monoclonal SERPINA1/Alpha 1 Antitrypsin Antibody. Validated in IP, IF, WB and tested in Human.

Recombinant Human Collagen alpha-1(XV) chain Protein, Untagged, E.coli-100ug
QP10332-ec-100ug 100ug
EUR 290

Recombinant Chicken Collagen alpha-1(XII) chain Protein, His, E.coli-100ug
QP5851-ec-100ug 100ug
EUR 707

Recombinant Chicken Collagen alpha-1(XII) chain Protein, His, Yeast-100ug
QP5851-ye-100ug 100ug
EUR 788

Recombinant Mouse ENO1/ Enolase 1/ alpha-enolase Protein, His, E.coli-100ug
QP5984-ec-100ug 100ug
EUR 571

Recombinant Human Proteasome subunit alpha type-1 Protein, His, E.coli-100ug
QP6543-ec-100ug 100ug
EUR 408

Recombinant Human Collagen alpha-1(XII) chain Protein, His, E.coli-100ug
QP8023-ec-100ug 100ug
EUR 408

Recombinant Human ENO1/ Enolase 1/ alpha-enolase Protein, GST, E.coli-100ug
QP8407-ec-100ug 100ug
EUR 408

Recombinant Human Collagen alpha-1(IV) chain Protein, GST, E.coli-100ug
QP8716-ec-100ug 100ug
EUR 408

Recombinant Human Collagen alpha-1(XVIII) chain Protein, GST, E.coli-100ug
QP8749-ec-100ug 100ug
EUR 408

Recombinant Human Collagen alpha-1(XVIII) chain Protein, His, Yeast-100ug
QP8749-ye-100ug 100ug
EUR 480

Recombinant S. cerevisiae Alpha-galactosidase 1 Protein, His-SUMO, E.coli-100ug
QP7286-ec-100ug 100ug
EUR 707

Recombinant Human Collagen alpha-1(XVII) chain Protein, His, E.coli-100ug
QP8920-ec-100ug 100ug
EUR 408

Recombinant Human Collagen alpha-1(XI) chain Protein, GST, Yeast-100ug
QP9074-ye-100ug 100ug
EUR 670

Recombinant Rat Collagen alpha-1(I) chain Protein, His, Yeast-100ug
QP9077-ye-100ug 100ug
EUR 571

Recombinant Human Transcription intermediary factor 1-alpha Protein, His, Yeast-100ug
QP6842-ye-100ug 100ug
EUR 480

Recombinant Sheep IL10/ Interleukin-10 Protein, His, Yeast-100ug
QP9777-ye-100ug 100ug
EUR 788

Recombinant Human IL16/ Interleukin-16 Protein, Untagged, E.coli-100ug
QP10303-ec-100ug 100ug
EUR 1678

Recombinant Human IL2/ Interleukin-2 Protein, Untagged, E.coli-100ug
QP10309-ec-100ug 100ug
EUR 326

Recombinant Human IL4/ Interleukin-4 Protein, Untagged, E.coli-100ug
QP10311-ec-100ug 100ug
EUR 870

Recombinant Human IL10/ Interleukin-10 Protein, Untagged, E.coli-100ug
QP10318-ec-100ug 100ug
EUR 1678

Recombinant Human IL19/ Interleukin-19 Protein, Untagged, E.coli-100ug
QP10324-ec-100ug 100ug
EUR 1678

Recombinant Human IL20/ Interleukin-20 Protein, Untagged, E.coli-100ug
QP10325-ec-100ug 100ug
EUR 1678

Recombinant Human IL22/ Interleukin 22 Protein, Untagged, E.coli-100ug
QP10327-ec-100ug 100ug
EUR 1678

Recombinant Macaque IL4/ Interleukin-4 Protein, Untagged, E.coli-100ug
QP10337-ec-100ug 100ug
EUR 1024

Recombinant Macaque IL16/ Interleukin-16 Protein, Untagged, E.coli-100ug
QP10443-ec-100ug 100ug
EUR 1995

Recombinant Mouse IL4/ Interleukin-4 Protein, Untagged, E.coli-100ug
QP10453-ec-100ug 100ug
EUR 870

Recombinant Mouse IL10/ Interleukin-10 Protein, Untagged, E.coli-100ug
QP10458-ec-100ug 100ug
EUR 1678

Recombinant Mouse IL16/ Interleukin-16 Protein, Untagged, E.coli-100ug
QP10461-ec-100ug 100ug
EUR 1995

Recombinant Mouse IL21/ Interleukin 21 Protein, Untagged, E.coli-100ug
QP10462-ec-100ug 100ug
EUR 1678

Recombinant Mouse IL22/ Interleukin 22 Protein, Untagged, E.coli-100ug
QP10463-ec-100ug 100ug
EUR 1678

Recombinant Human IL2/ Interleukin-2 Protein, GST, E.coli-100ug
QP6216-ec-100ug 100ug
EUR 408

Recombinant Human IL2/ Interleukin-2 Protein, His, Yeast-100ug
QP6216-ye-100ug 100ug
EUR 480

Recombinant Rabbit IL2/ Interleukin-2 Protein, His, E.coli-100ug
QP6218-ec-100ug 100ug
EUR 707

Recombinant Dog IL4/ Interleukin-4 Protein, His, E.coli-100ug
QP6222-ec-100ug 100ug
EUR 707

Recombinant Human IL10/ Interleukin-10 Protein, GST, E.coli-100ug
QP8553-ec-100ug 100ug
EUR 408

Recombinant Human IL4/ Interleukin-4 Protein, His, E.coli-100ug
QP8557-ec-100ug 100ug
EUR 408

Recombinant Human IL4/ Interleukin-4 Protein, His, Yeast-100ug
QP8557-ye-100ug 100ug
EUR 480

Recombinant Bovine IL10/ Interleukin-10 Protein, His, Yeast-100ug
QP9204-ye-100ug 100ug
EUR 788

Recombinant Macaque IL10/ Interleukin-10 Protein, His, Yeast-100ug
QP9205-ye-100ug 100ug
EUR 788

Recombinant other Gliadin Alpha Wheat Protein, His, E.coli-100ug
QP11983-100ug 100ug
EUR 218

Recombinant Mouse CXCL1/ GRO-alpha Protein, Untagged, E.coli-100ug
QP1455-100ug 100ug
EUR 490

Recombinant Human Interferon alpha 2a Protein, Untagged, E.coli-100ug
QP5364-100ug 100ug
EUR 237

Recombinant E.coli Glutamate decarboxylase alpha Protein, His, E.coli-100ug
QP6947-100ug 100ug
EUR 771

Anti-Hif3 alpha Antibody
A03805-1 100ug
EUR 455
Description: Rabbit Polyclonal Hif3 alpha Antibody. Validated in WB and tested in Mouse.

Anti-c-Myc Antibody [9E10], Unconjugated-100ug
QAB102-100ug 100ug
EUR 216

Anti-CD4 Antibody [RPA-T4], Unconjugated-100ug
QAB12-100ug 100ug
EUR 123

Anti-CD8a Antibody [53-6.7], Unconjugated-100ug
QAB16-100ug 100ug
EUR 131

Anti-CD8a Antibody [RPA-T8], Unconjugated-100ug
QAB19-100ug 100ug
EUR 149

Anti-CD3e Antibody [145-2C11], Unconjugated-100ug
QAB2-100ug 100ug
EUR 123

Anti-CD45 Antibody [30-F11], Unconjugated-100ug
QAB40-100ug 100ug
EUR 149

Anti-CD80 Antibody [16-10A1], Unconjugated-100ug
QAB50-100ug 100ug
EUR 182

Anti-CD161 Antibody [HP-3G10], Unconjugated-100ug
QAB60-100ug 100ug
EUR 157

Anti-IL-4 Antibody [11B11], Unconjugated-100ug
QAB81-100ug 100ug
EUR 149

Rabbit Anti Human Interleukin-1 Alpha Polyclonal Antibody
CPBT-65373RH 0.1 mg
EUR 881

Despite the advantages of antibodies monocolonal, some restrictions provide the background is accepted for alternative agents such as aptamers that can replace the antibodies. In the current study, aptamer isolation of the IL-5 molecule was intended, according to the valuable benefits of aptamers more antibodies.