Ghrelin is a peptide hormone with a direct or indirect effect on obesity and asthma. More data is needed to understand the effects of ghrelin on the control and pathogenesis of this disease. The purpose of this study was to evaluate the level of ghrelin in selected groups of children to identify the relationship between serum ghrelin, obesity and asthma severity. The study involved 401 school children were selected from the region of Najran and grouped into non-obese people with asthma, obese patients with asthma, obese non-asthmatics and controls (non-obese non-asthmatics). levels of ghrelin, interleukin (IL) -4, IL-5 and IL-21 were determined by ELISA.
The mean value of ghrelin were not significantly elevated in obese children compared with children of non-obese. The highest blood ghrelin values are in the non-obese asthma group. Serum ghrelin, IL-4 and IL-21 levels were significantly increased in children with asthma compared with children of non-asthma (p <0.05), and there was a significant positive correlation between ghrelin and IL-4, IL -5, and IL-21 in children with asthma.
Furthermore, ghrelin, the level of IL-4 and IL-21 were significantly higher in patients with uncontrolled asthma compared to controlled-asthmatic children (p <0.05). Asthma is a significant risk factor only for values higher ghrelin. This study provides evidence that supports the anti-inflammatory role of ghrelin in the pathogenesis of asthma. Asthma may be considered as an important determinant of the values of ghrelin were higher in children.

Anti interleukin – 5 -neutralizing antibody attenuates cardiac injury and cardiac dysfunction by aggravating the inflammatory response in the doxorubicin-treated mice.
Previous studies have shown that interleukin (ILS) are closely associated with doxorubicin (DOX) -induced cardiac injury. IL-5 is an important member of the family IL, and the study was conducted to investigate whether IL-5 affect DOX-induced cardiac injury and the underlying mechanisms. The heart of the IL-5 expression was first detected and the results showed that the heart of IL-5 levels were significantly lowered in DOX-treated mice, and IL-5 is mainly derived from the heart mo.
In addition, some mice DOX-treated received injections of antibodies anti-IL-5-neutralizing (NAB), and we found that treatment with mouse anti-IL-5 NAB significantly up-regulated levels of markers of myocardial injury, exacerbated cardiac dysfunction, increased M1 macrophages (mO1) and a decrease in M2 macrophages (MO2) differentiation, and promoted the expression of markers of apoptosis.
In addition, the effect of mouse IL-5 TLV on differentiation mo DOX-induced and its role in cardiomyocyte rat (MCM) of apoptotic cells detected in vitro, and the results exhibited that the mouse IL-5 NAB promoted differentiation MO1 but inhibited the differentiation of MO2 in vitro and commuted apoptosis the MCM cells. Our results found the mouse anti-IL-5 NAB aggravated DOX-induced cardiac injury and dysfunction by reducing the inflammatory response and myocardial cell apoptosis.
This article is protected by copyright. All rights reserved. Asthma is a chronic inflammatory disorder is associated with high levels of cytokines such as interleukin-5 (IL-5), which plays an important role in the differentiation and maturation of eosinophils. Thus, blockage of IL-5 using mepalizumab has been considered a promising therapeutic approach for asthma.
IL-1 alpha, Interleukin-1 alpha, rat |
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RC252-12A | Bio Basic | 2ug | EUR 125.26 |
Rat Interleukin-1 alpha (IL-1 alpha) Antibody |
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32524-05111 | AssayPro | 150 ug | EUR 313.2 |
IL-1 alpha, Interleukin-1 alpha, human |
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RC212-12A | Bio Basic | 2ug | EUR 125.26 |
Human Interleukin-1 alpha (IL-1 alpha) Antibody |
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32196-05111 | AssayPro | 150 ug | EUR 313.2 |
Human Interleukin-1 alpha |
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90169-A | BPS Bioscience | 2 µg | EUR 130 |
Description: Recombinant Interleukin-1a is a disulfide-linked monomer protein consisting of 160 amino acid residues and migrates as an approximately 18 kDa protein under non-reducing conditions and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human Interleukin-1 alpha mature chain was expressed in E. coli. _x000D__x000D_ |
Human Interleukin-1 alpha |
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90169-B | BPS Bioscience | 10 µg | EUR 205 |
Description: Recombinant Interleukin-1a is a disulfide-linked monomer protein consisting of 160 amino acid residues and migrates as an approximately 18 kDa protein under non-reducing conditions and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human Interleukin-1 alpha mature chain was expressed in E. coli. _x000D__x000D_ |
Mouse Interleukin-1 alpha |
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90171-A | BPS Bioscience | 2 µg | EUR 130 |
Description: Recombinant IL-1a is a disulfide-linked monomer protein consisting of 157 amino acid residues and migrates as an approximately 18 kDa protein under non-reducing conditions and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding murine Interleukin-1 alpha mature chain was expressed in E. coli. _x000D__x000D_ |
Mouse Interleukin-1 alpha |
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90171-B | BPS Bioscience | 10 µg | EUR 205 |
Description: Recombinant IL-1a is a disulfide-linked monomer protein consisting of 157 amino acid residues and migrates as an approximately 18 kDa protein under non-reducing conditions and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding murine Interleukin-1 alpha mature chain was expressed in E. coli. _x000D__x000D_ |
Interleukin 1 Alpha (IL1A) Antibody |
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20-abx109930 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx104904 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx101891 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx101892 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx173020 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx173021 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx173022 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx173023 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx173024 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx177052 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx177054 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx177055 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody |
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20-abx210848 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody |
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20-abx211106 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx132312 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody |
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20-abx326469 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody |
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20-abx113230 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody |
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abx018000-100ug | Abbexa | 100 ug | EUR 460.8 |
Interleukin 1 Alpha (IL1A) Antibody |
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abx036412-100ug | Abbexa | 100 ug | EUR 469.2 |
Interleukin 1 Alpha (IL1A) Antibody |
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abx033027-400ul | Abbexa | 400 ul | EUR 627.6 |
Interleukin 1 Alpha (IL1A) Antibody |
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abx033027-80l | Abbexa | 80 µl | EUR 343.2 |
Interleukin 1 Alpha (IL1a) Antibody |
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20-abx101885 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx101886 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx101887 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody |
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20-abx101888 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx101889 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx101890 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx128132 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx129396 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx129503 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx131946 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx131947 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody |
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20-abx131948 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody |
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20-abx131949 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody |
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20-abx131950 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody |
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20-abx131951 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody |
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20-abx001782 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody |
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abx011004-100ul | Abbexa | 100 ul | EUR 493.2 |
Interleukin 1 Alpha (IL1A) Antibody |
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20-abx300512 | Abbexa |
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Interleukin-1 Alpha (IL1A) Antibody |
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20-abx225241 | Abbexa |
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Human Interleukin-36 alpha (Interleukin-36 alpha) ELISA Kit |
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QY-E05578 | Qayee Biotechnology | 96T | EUR 433.2 |
IL-1 alpha, Interleukin-1 alpha, murine (mouse) |
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RC232-12A | Bio Basic | 2ug | EUR 125.26 |
Interleukin 1 Alpha (IL1a) Antibody (APC) |
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20-abx177053 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody (HRP) |
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20-abx108418 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody (HRP) |
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20-abx300513 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody (FITC) |
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20-abx106997 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody Pair |
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abx117488-1pair5x96wellplates | Abbexa | 1 pair (5x96 well plates) | EUR 1212 |
Interleukin 1 Alpha (IL1a) Antibody Pair |
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20-abx370238 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody Pair |
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20-abx370358 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody Pair |
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20-abx370543 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody Pair |
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20-abx370642 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody Pair |
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20-abx370733 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody (FITC) |
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20-abx273853 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody (FITC) |
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20-abx300514 | Abbexa |
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Active Interleukin 1 Alpha (IL1a) |
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4-APA071Hu01 | Cloud-Clone |
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Description: Recombinant Human Interleukin 1 Alpha expressed in: E.coli |
Goat Anti Rat Interleukin-1 Alpha Polyclonal Antibody |
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CPBT-65377GR | Creative Diagnostics | 0.1 mg | EUR 1057.2 |
Rat Monoclonal Anti-Mouse Interleukin-10 IgG |
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AB-11310 | Alpha Diagnostics | 100 ug | EUR 416.4 |
Human Interleukin-1 alpha (IL1A) |
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1-CSB-RP065654h | Cusabio |
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Description: Recombinant Human Interleukin-1 alpha(IL1A) expressed in E.coli |
Human Interleukin-1 alpha (IL1A) |
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1-CSB-RP065694h | Cusabio |
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Description: Recombinant Human Interleukin-1 alpha(IL1A) expressed in E.coli |
Human Interleukin-1 alpha (IL1A) |
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1-CSB-YP011613HUc7 | Cusabio |
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Description: Recombinant Human Interleukin-1 alpha(IL1A) expressed in Yeast |
Rat Monoclonal Anti-Mouse Interleukin-2 IgG |
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AB-10510 | Alpha Diagnostics | 100 ug | EUR 416.4 |
Rat Monoclonal Anti-Mouse Interleukin-4 IgG |
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AB-10810 | Alpha Diagnostics | 100 ug | EUR 416.4 |
Mouse Monoclonal Anti-Human Interleukin-10 IgG |
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AB-11210 | Alpha Diagnostics | 100 ug | EUR 416.4 |
Mouse Monoclonal Anti-Human Interleukin-15 IgG |
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AB-11510 | Alpha Diagnostics | 100 ug | EUR 416.4 |
Interleukin 1 Alpha (IL1a) Antibody (Biotin) |
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20-abx271654 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody (Biotin) |
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20-abx271680 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody (Biotin) |
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20-abx271733 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody (Biotin) |
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20-abx271911 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody (Biotin) |
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20-abx105579 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody (Biotin) |
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20-abx273056 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody (Biotin) |
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20-abx273137 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody (Biotin) |
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20-abx273464 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody (Biotin) |
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20-abx274415 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody (Biotin) |
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20-abx274447 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody (Biotin) |
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20-abx274500 | Abbexa |
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Interleukin 1 Alpha (IL1a) Antibody (Biotin) |
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20-abx274526 | Abbexa |
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Interleukin 1 Alpha (IL1A) Antibody (Biotin) |
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20-abx300515 | Abbexa |
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Rat Monoclonal Anti-Mouse Interleukin-12p40 IgG |
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AB-11410 | Alpha Diagnostics | 100 ug | EUR 416.4 |
Rat Monoclonal Anti-Mouse Interleukin-12p75 IgG |
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AB-20910 | Alpha Diagnostics | 100 ug | EUR 416.4 |
Interleukin-1 Alpha (IL1A-S87) Antibody |
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abx033026-400ul | Abbexa | 400 ul | EUR 627.6 |
Interleukin-1 Alpha (IL1A-S87) Antibody |
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abx033026-80l | Abbexa | 80 µl | EUR 343.2 |
Mouse Monoclonal Anti-Human Interleukin-2 IgG |
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AB-10210 | Alpha Diagnostics | 100 ug | EUR 416.4 |
Mouse Monoclonal Anti-Human Interleukin-3 IgG |
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AB-10610 | Alpha Diagnostics | 100 ug | EUR 416.4 |
Mouse Monoclonal Anti-Human Interleukin-4 IgG |
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AB-10710 | Alpha Diagnostics | 100 ug | EUR 416.4 |
Mouse Monoclonal Anti-Human Interleukin-6 IgG |
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AB-10910 | Alpha Diagnostics | 100 ug | EUR 416.4 |
Mouse Monoclonal Anti-Human Interleukin-7 IgG |
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AB-11010 | Alpha Diagnostics | 100 ug | EUR 416.4 |
Mouse Monoclonal Anti-Human Interleukin-8 IgG |
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AB-11110 | Alpha Diagnostics | 100 ug | EUR 416.4 |
Rabbit Anti Human Interleukin-1 Alpha Polyclonal Antibody |
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CPBT-65373RH | Creative Diagnostics | 0.1 mg | EUR 1057.2 |
Rabbit Anti Mouse Interleukin-1 Alpha Polyclonal Antibody |
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CPBT-65375RM | Creative Diagnostics | 0.1 mg | EUR 1057.2 |
Recombinant Interleukin 1 Alpha (IL1a) |
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4-RPA071Bo01 | Cloud-Clone |
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Description: Recombinant Bovine Interleukin 1 Alpha expressed in: E.coli |
Recombinant Interleukin 1 Alpha (IL1a) |
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4-RPA071Ca01 | Cloud-Clone |
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Description: Recombinant Dog Interleukin 1 Alpha expressed in: E.coli |
Recombinant Interleukin 1 Alpha (IL1a) |
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4-RPA071Ca02 | Cloud-Clone |
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Description: Recombinant Dog Interleukin 1 Alpha expressed in: E.coli |
Recombinant Interleukin 1 Alpha (IL1a) |
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4-RPA071Cp01 | Cloud-Clone |
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Description: Recombinant Goat Interleukin 1 Alpha expressed in: E.coli |
Recombinant Interleukin 1 Alpha (IL1a) |
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4-RPA071Eq01 | Cloud-Clone |
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Description: Recombinant Horse Interleukin 1 Alpha expressed in: E.coli |
Recombinant Interleukin 1 Alpha (IL1a) |
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4-RPA071Gu01 | Cloud-Clone |
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Description: Recombinant Guinea pig Interleukin 1 Alpha expressed in: E.coli |
Recombinant Interleukin 1 Alpha (IL1a) |
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4-RPA071Hu01 | Cloud-Clone |
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Description: Recombinant Human Interleukin 1 Alpha expressed in: E.coli |
Recombinant Interleukin 1 Alpha (IL1a) |
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4-RPA071Hu02 | Cloud-Clone |
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Description: Recombinant Human Interleukin 1 Alpha expressed in: E.coli |
Recombinant Interleukin 1 Alpha (IL1a) |
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4-RPA071Mu01 | Cloud-Clone |
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Description: Recombinant Mouse Interleukin 1 Alpha expressed in: E.coli |
Recombinant Interleukin 1 Alpha (IL1a) |
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4-RPA071Mu02 | Cloud-Clone |
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Description: Recombinant Mouse Interleukin 1 Alpha expressed in: E.coli |
Recombinant Interleukin 1 Alpha (IL1a) |
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4-RPA071Po01 | Cloud-Clone |
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Description: Recombinant Pig Interleukin 1 Alpha expressed in: E.coli |
Recombinant Interleukin 1 Alpha (IL1a) |
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4-RPA071Ra01 | Cloud-Clone |
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Description: Recombinant Rat Interleukin 1 Alpha expressed in: E.coli |
Recombinant Interleukin 1 Alpha (IL1a) |
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4-RPA071Rb01 | Cloud-Clone |
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Description: Recombinant Rabbit Interleukin 1 Alpha expressed in: E.coli |
Recombinant Rat Interleukin-1 alpha |
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7-00757 | CHI Scientific | 2µg | Ask for price |
Recombinant Rat Interleukin-1 alpha |
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7-00758 | CHI Scientific | 10µg | Ask for price |
Recombinant Rat Interleukin-1 alpha |
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7-00759 | CHI Scientific | 100µg | Ask for price |
Recombinant Rat Interleukin-1 alpha |
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CC097-002 | GenDepot | 2ug | EUR 351.6 |
Recombinant Rat Interleukin-1 alpha |
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CC097-010 | GenDepot | 10ug | EUR 489.6 |
Recombinant Rat Interleukin-1 alpha |
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CC097-100 | GenDepot | 100ug | EUR 3786 |
Rat Interleukin-1 alpha (IL-1 alpha) Antibody (Biotin Conjugate) |
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32524-05121 | AssayPro | 150 ug | EUR 442.8 |
Rabbit Anti-Human Interleukin-1 receptor-like 1 (IL1RL1) IgG (aff pure) |
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AB-23064-A | Alpha Diagnostics | 100ug | EUR 578.4 |
Rabbit Anti-Human Interleukin-1 receptor-like 1 (IL1RL1) IgG (aff pure) |
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AB-23065-A | Alpha Diagnostics | 100ug | EUR 578.4 |
Rabbit Anti-Human Interleukin-1 receptor-like 1 (IL1RL1) IgG (aff pure) |
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AB-23066-A | Alpha Diagnostics | 100ug | EUR 578.4 |
Human Interleukin-1 alpha (IL-1 alpha) Antibody (Biotin Conjugate) |
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32196-05121 | AssayPro | 150 ug | EUR 442.8 |
Recombinant Human Interleukin-1 alpha |
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7-00748 | CHI Scientific | 2µg | Ask for price |
Recombinant Human Interleukin-1 alpha |
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7-00749 | CHI Scientific | 10µg | Ask for price |
Recombinant Human Interleukin-1 alpha |
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7-00750 | CHI Scientific | 1mg | Ask for price |
Recombinant Mouse Interleukin-1 alpha |
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7-00754 | CHI Scientific | 2µg | Ask for price |
Recombinant Mouse Interleukin-1 alpha |
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7-00755 | CHI Scientific | 10µg | Ask for price |
Recombinant Mouse Interleukin-1 alpha |
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7-00756 | CHI Scientific | 1mg | Ask for price |
Recombinant Human Interleukin-1 alpha |
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CC032-002 | GenDepot | 2ug | EUR 351.6 |
Recombinant Human Interleukin-1 alpha |
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CC032-010 | GenDepot | 10ug | EUR 489.6 |
Recombinant Human Interleukin-1 alpha |
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CC032-101 | GenDepot | 1mg | EUR 10752 |
Recombinant Mouse Interleukin-1 alpha |
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CC074-002 | GenDepot | 2ug | EUR 351.6 |
Recombinant Mouse Interleukin-1 alpha |
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CC074-010 | GenDepot | 10ug | EUR 489.6 |
Recombinant Mouse Interleukin-1 alpha |
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CC074-101 | GenDepot | 1mg | EUR 10752 |
Rat Interleukin 1 Alpha (IL1A) Protein |
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20-abx262243 | Abbexa |
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Pig Interleukin 1 Alpha (IL1A) Protein |
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20-abx263471 | Abbexa |
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Dog Interleukin 1 Alpha (IL1a) Protein |
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20-abx067380 | Abbexa |
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Pig Interleukin 1 Alpha (IL1a) Protein |
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20-abx067385 | Abbexa |
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Cow Interleukin 1 Alpha (IL1a) Protein |
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20-abx069738 | Abbexa |
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Rat Interleukin 1 Alpha (IL1a) Protein |
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20-abx069739 | Abbexa |
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Cow Interleukin 1 Alpha (IL1A) Protein |
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abx670140-5ug | Abbexa | 5 ug | EUR 493.2 |
Dog Interleukin 1 Alpha (IL1a) Protein |
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20-abx166352 | Abbexa |
|
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Horse Interleukin 1 Alpha (IL1a) ELISA |
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QY-E120051 | Qayee Biotechnology | 96T | EUR 573.6 |
Goat Interleukin 1 Alpha (IL1a) Protein |
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20-abx067381 | Abbexa |
|
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Goat Anti Rat Interleukin-1 Alpha Polyclonal Antibody,Biotin |
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CPBT-65376GR | Creative Diagnostics | 50 µg | EUR 1057.2 |
Rat Monoclonal Anti-Mouse Interleukin-2 receptor IgG |
|||
AB-10310 | Alpha Diagnostics | 100 ug | EUR 416.4 |
Rabbit interleukin 36 alpha |
|||
ERTI0397 | Abclonal | 96Tests | EUR 625.2 |
Recombinant Porcine Interleukin-1 alpha |
|||
7-00760 | CHI Scientific | 2µg | Ask for price |
Recombinant Porcine Interleukin-1 alpha |
|||
7-00761 | CHI Scientific | 10µg | Ask for price |
Recombinant Porcine Interleukin-1 alpha |
|||
7-00762 | CHI Scientific | 100µg | Ask for price |
Recombinant Porcine Interleukin-1 alpha |
|||
CC090-002 | GenDepot | 2ug | EUR 351.6 |
Recombinant Porcine Interleukin-1 alpha |
|||
CC090-010 | GenDepot | 10ug | EUR 489.6 |
Despite the advantages of antibodies monocolonal, some restrictions provide the background is accepted for alternative agents such as aptamers that can replace the antibodies. In the current study, aptamer isolation of the IL-5 molecule was intended, according to the valuable benefits of aptamers more antibodies.