In this study, we focus on the role of serum interleukin 6 (IL-6) concentration in predicting 5-year cardiovascular mortality in hemodialysis patients using the dialyzer reuse.We low-flux measured serum concentrations of IL-6 in 236 hemodialysis patients (138 males and 98 women) to predict the 5-year cardiovascular mortality.
We assess the basic demographics of all patients who had a mean age of 44 years and a median duration of 38.5 months hemodialysis. We divided all patients into two equal groups based on serum IL-6 concentration: G1 (n = 118) with serum IL-6 concentrations <6.78 pg / L and G2 (n = 118) with serum IL-6 concentration ≥ 6 , 78 pg /L.After 5 years of follow-up, 45 patients died of cardiovascular causes (19.1%).
lipid disorders, hemoglobin, serum albumin, β2-M, and IL-6 concentration is an independent risk factor for predicting cardiovascular mortality during the 60-month follow-up in patients on hemodialysis. Based on Kaplan-Meier analysis, we realized that patients with higher concentrations of interleukin 6 (G2) had a cardiovascular mortality rate was significantly higher than in G1 patients (log-rank test p <0.001).
Serum IL-6 concentration was a better predictor of 5-year cardiovascular mortality than the high-sensitivity C-reactive protein in hemodialysis patients using reuse the dialyzer low-flux (AUC = 0.818; p <0.001; cut-off value: 8.055 pg / mL, Se = 77.8%, Sp = 78.5%). Serum IL-6 concentration was a better predictor of cardiovascular mortality compared 5 years of high sensitivity C-reactive protein in maintenance hemodialysis patients using low-flux dialysis reuse.
Interleukin 6 is a better predictor of 5 -year cardiovascular mortality than high-sensitivity C-reactive protein in hemodialysis patients using reused low-flux dialyzers.Identification of new splice variants of mouse and human interleukin – 5 .
Interleukins and their receptors expression are often regulated by alternative splicing. alternative isoforms of IL-5 receptor α-chain is well studied; However, no data on functional alternative splice variant of IL-5 has been reported today. In this study, we describe a new splice variants of mouse and human IL-5. The new form is found during the analysis of PCR products amplified from mouse lymphoid tissues that are different primer pair is designed for full-length clone MIL-5 ORF.
A single short isoform MIL-5 detected along with the full-length canonical Cona-induced mRNA in lymphoid cells isolated from spleen, thymus, lymph nodes and blood. It was 30-40 nt shorter, and less than the classical form. Analysis of additional sequences such as MIL-5, revealing that he has no exon-2 (δ2). Using RT-PCR with primers specific splice we obtain additional evidence for the expression of form δ2.
To verify whether the MIL-5δ2 transcripts translated into proteins, the coding sequence in accordance with the full form and δ2 of MIL-5 cloned into the expression plasmid. After transfection into human 293T cell lines, we found that the short form of MIL-5 proteins are expressed in cells and is secreted into the supernatant, but at a reduced rate than that detected for the full MIL-5 isoform.
Fluorescence microscope examination revealed a partial MIL-5δ2 translocation into the cytoplasm, while MIL-5 stayed mostly in the endoplasmic reticulum. This may explain why the rate of protein expression δ2 reduced. Using a similar set of experimental approaches, we received evidence that human IL-5 mRNA has δ2 splice forms (HIL-5δ2) as well. It can firmly be detected by RT-PCR in PHA-activated mononuclear cells isolated from peripheral blood of healthy individuals or patients with asthma.
Interleukin 10 (IL10) Polyclonal Antibody
MBS2032638-01mL
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0.1mL
EUR 150
Interleukin 10 (IL10) Polyclonal Antibody
MBS2032638-02mL
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0.2mL
EUR 175
Interleukin 10 (IL10) Polyclonal Antibody
MBS2032638-05mL
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0.5mL
EUR 265
Interleukin 10 (IL10) Polyclonal Antibody
MBS2032638-1mL
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1mL
EUR 315
Interleukin 10 (IL10) Polyclonal Antibody
MBS2032638-5mL
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5mL
EUR 845
Interleukin 10 (IL10) Polyclonal Antibody
MBS2032702-01mL
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0.1mL
EUR 150
Interleukin 10 (IL10) Polyclonal Antibody
MBS2032702-02mL
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0.2mL
EUR 175
Interleukin 10 (IL10) Polyclonal Antibody
MBS2032702-05mL
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0.5mL
EUR 270
Interleukin 10 (IL10) Polyclonal Antibody
MBS2032702-1mL
MyBiosource
1mL
EUR 315
Interleukin 10 (IL10) Polyclonal Antibody
MBS2032702-5mL
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5mL
EUR 855
Interleukin 10 (IL10) Polyclonal Antibody (Dog)
4-PAA056Ca01
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Description: A Rabbit polyclonal antibody against Dog Interleukin 10 (IL10)
Interleukin 10 (IL10) Polyclonal Antibody (Dog)
4-PAA056Ca06
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Description: A Rabbit polyclonal antibody against Dog Interleukin 10 (IL10)
Interleukin 10 (IL10) Polyclonal Antibody (Rat)
4-PAA056Ra01
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Description: A Rabbit polyclonal antibody against Rat Interleukin 10 (IL10)
Interleukin 10 (IL10) Polyclonal Antibody (Rat)
4-PAA056Ra06
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Polyclonal Antibody to Interleukin 10 (IL10)
MBS2033906-01mL
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Polyclonal Antibody to Interleukin 10 (IL10)
MBS2033906-02mL
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Polyclonal Antibody to Interleukin 10 (IL10)
MBS2033906-05mL
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0.5mL
EUR 395
Polyclonal Antibody to Interleukin 10 (IL10)
MBS2033906-1mL
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1mL
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Polyclonal Antibody to Interleukin 10 (IL10)
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5mL
EUR 1335
Polyclonal Antibody to Interleukin 10 (IL10)
MBS2111339-01mL
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0.1mL
EUR 170
Polyclonal Antibody to Interleukin 10 (IL10)
MBS2111339-02mL
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0.2mL
EUR 215
Polyclonal Antibody to Interleukin 10 (IL10)
MBS2111339-05mL
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EUR 350
Polyclonal Antibody to Interleukin 10 (IL10)
MBS2111339-1mL
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1mL
EUR 425
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5mL
EUR 1160
Polyclonal Antibody to Interleukin 10 (IL10)
MBS2111744-01mL
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0.1mL
EUR 180
Polyclonal Antibody to Interleukin 10 (IL10)
MBS2111744-02mL
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EUR 225
Polyclonal Antibody to Interleukin 10 (IL10)
MBS2111744-05mL
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EUR 380
Polyclonal Antibody to Interleukin 10 (IL10)
MBS2111744-1mL
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1mL
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MBS2111744-5mL
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5mL
EUR 1280
Polyclonal Antibody to Interleukin 10 (IL10)
MBS2111745-01mL
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EUR 190
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MBS2111745-02mL
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EUR 235
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MBS2111745-05mL
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MBS2111745-1mL
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1mL
EUR 490
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MBS2111745-5mL
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5mL
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Polyclonal Antibody to Interleukin 10 (IL10)
MBS2007221-01mL
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EUR 155
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MBS2007221-02mL
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MBS2007221-05mL
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EUR 275
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MBS2007221-1mL
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EUR 320
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MBS2007221-5mL
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EUR 875
Polyclonal Antibody to Interleukin 10 (IL10)
MBS2007228-01mL
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EUR 150
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MBS2007228-02mL
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EUR 175
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MBS2007228-05mL
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EUR 270
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MBS2007228-1mL
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1mL
EUR 315
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MBS2007228-5mL
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5mL
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Polyclonal Antibody to Interleukin 10 (IL10)
MBS2014655-01mL
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EUR 150
Polyclonal Antibody to Interleukin 10 (IL10)
MBS2014655-02mL
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0.2mL
EUR 175
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MBS2014655-05mL
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0.5mL
EUR 265
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MBS2014655-1mL
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1mL
EUR 315
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MBS2014655-5mL
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5mL
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Polyclonal Antibody to Interleukin 10 (IL10)
MBS2026173-01mL
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EUR 175
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MBS2026173-02mL
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EUR 220
Polyclonal Antibody to Interleukin 10 (IL10)
MBS2026173-05mL
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EUR 365
Polyclonal Antibody to Interleukin 10 (IL10)
MBS2026173-1mL
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1mL
EUR 445
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MBS2026173-5mL
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5mL
EUR 1220
Polyclonal Antibody to Interleukin 10 (IL10)
MBS2026258-01mL
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EUR 180
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MBS2026258-02mL
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EUR 225
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MBS2026258-05mL
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MBS2026258-1mL
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1mL
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MBS2026258-5mL
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Polyclonal Antibody to Interleukin 10 (IL10)
MBS2028184-01mL
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EUR 170
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MBS2028184-02mL
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EUR 215
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MBS2028184-05mL
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0.5mL
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MBS2028184-1mL
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1mL
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MBS2028184-5mL
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5mL
EUR 1160
Polyclonal Antibody to Interleukin 10 (IL10)
MBS2026931-01mL
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0.1mL
EUR 190
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MBS2026931-02mL
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EUR 230
Polyclonal Antibody to Interleukin 10 (IL10)
MBS2026931-05mL
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0.5mL
EUR 390
Polyclonal Antibody to Interleukin 10 (IL10)
MBS2026931-1mL
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1mL
EUR 475
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MBS2026931-5mL
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5mL
EUR 1310
Polyclonal Antibody to Interleukin 10 (IL10)
MBS2090481-01mL
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EUR 170
Polyclonal Antibody to Interleukin 10 (IL10)
MBS2090481-02mL
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EUR 215
Polyclonal Antibody to Interleukin 10 (IL10)
MBS2090481-05mL
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EUR 350
Polyclonal Antibody to Interleukin 10 (IL10)
MBS2090481-1mL
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1mL
EUR 425
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MBS2090481-5mL
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5mL
EUR 1160
Polyclonal Antibody to Interleukin 10 (IL10)
PAA056Bo01
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100ul
EUR 265
Polyclonal Antibody to Interleukin 10 (IL10)
PAA056Ca01
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100ul
EUR 252
Polyclonal Antibody to Interleukin 10 (IL10)
PAA056Cp01
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100ul
EUR 272
Polyclonal Antibody to Interleukin 10 (IL10)
PAA056Eq01
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100ul
EUR 272
Polyclonal Antibody to Interleukin 10 (IL10)
PAA056Ga01
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100ul
EUR 239
Polyclonal Antibody to Interleukin 10 (IL10)
PAA056Hu01
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100ul
EUR 172
Polyclonal Antibody to Interleukin 10 (IL10)
PAA056Hu02
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100ul
EUR 171
Polyclonal Antibody to Interleukin 10 (IL10)
PAA056Mu01
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100ul
EUR 176
Polyclonal Antibody to Interleukin 10 (IL10)
PAA056Mu02
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100ul
EUR 227
Polyclonal Antibody to Interleukin 10 (IL10)
PAA056Po01
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100ul
EUR 265
Polyclonal Antibody to Interleukin 10 (IL10)
PAA056Ra01
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100ul
EUR 239
Polyclonal Antibody to Interleukin 10 (IL10)
PAA056Rb51
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100ul
EUR 239
Interleukin 10 (IL10) Polyclonal Antibody (Horse)
4-PAA056Eq01
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Horse Interleukin 10 (IL10)
Interleukin 10 (IL10) Polyclonal Antibody (Human)
4-PAA056Hu01
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Human Interleukin 10 (IL10)
Interleukin 10 (IL10) Polyclonal Antibody (Human)
4-PAA056Hu02
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Human Interleukin 10 (IL10)
Interleukin 10 (IL10) Polyclonal Antibody (Human)
4-PAA056Hu06
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Human Interleukin 10 (IL10)
Interleukin 10 (IL10) Polyclonal Antibody (Mouse)
4-PAA056Mu01
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Mouse Interleukin 10 (IL10)
Interleukin 10 (IL10) Polyclonal Antibody (Bovine)
4-PAA056Bo01
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Bovine Interleukin 10 (IL10)
Interleukin 10 (IL10) Polyclonal Antibody (Gallus)
4-PAA056Ga01
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Gallus Interleukin 10 (IL10)
Interleukin 10 (IL10) Polyclonal Antibody (Rabbit)
4-PAA056Rb51
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20ul 100ul 200ul 1ml 10ml
Description: A Guinea polyclonal antibody against Rabbit Interleukin 10 (IL10)
Interleukin 10 (IL10) Polyclonal Antibody (Dog), PE
4-PAA056Ca01-PE
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Dog Interleukin 10 (IL10). This antibody is labeled with PE.
Interleukin 10 (IL10) Polyclonal Antibody (Dog), PE
4-PAA056Ca06-PE
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Dog Interleukin 10 (IL10). This antibody is labeled with PE.
Interleukin 10 (IL10) Polyclonal Antibody (Rat), PE
4-PAA056Ra01-PE
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Rat Interleukin 10 (IL10). This antibody is labeled with PE.
Interleukin 10 (IL10) Polyclonal Antibody (Rat), PE
4-PAA056Ra06-PE
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Rat Interleukin 10 (IL10). This antibody is labeled with PE.
Interleukin 10 (IL10) Polyclonal Antibody (Dog), APC
4-PAA056Ca01-APC
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Dog Interleukin 10 (IL10). This antibody is labeled with APC.
Interleukin 10 (IL10) Polyclonal Antibody (Dog), Cy3
4-PAA056Ca01-Cy3
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Dog Interleukin 10 (IL10). This antibody is labeled with Cy3.
Interleukin 10 (IL10) Polyclonal Antibody (Dog), HRP
4-PAA056Ca01-HRP
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Dog Interleukin 10 (IL10). This antibody is labeled with HRP.
Interleukin 10 (IL10) Polyclonal Antibody (Dog), APC
4-PAA056Ca06-APC
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Dog Interleukin 10 (IL10). This antibody is labeled with APC.
Interleukin 10 (IL10) Polyclonal Antibody (Dog), Cy3
4-PAA056Ca06-Cy3
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Dog Interleukin 10 (IL10). This antibody is labeled with Cy3.
Interleukin 10 (IL10) Polyclonal Antibody (Dog), HRP
4-PAA056Ca06-HRP
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Dog Interleukin 10 (IL10). This antibody is labeled with HRP.
Interleukin 10 (IL10) Polyclonal Antibody (Rat), APC
4-PAA056Ra01-APC
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Rat Interleukin 10 (IL10). This antibody is labeled with APC.
Interleukin 10 (IL10) Polyclonal Antibody (Rat), Cy3
4-PAA056Ra01-Cy3
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Rat Interleukin 10 (IL10). This antibody is labeled with Cy3.
Interleukin 10 (IL10) Polyclonal Antibody (Rat), HRP
4-PAA056Ra01-HRP
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Rat Interleukin 10 (IL10). This antibody is labeled with HRP.
Interleukin 10 (IL10) Polyclonal Antibody (Rat), APC
4-PAA056Ra06-APC
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Rat Interleukin 10 (IL10). This antibody is labeled with APC.
Interleukin 10 (IL10) Polyclonal Antibody (Rat), Cy3
4-PAA056Ra06-Cy3
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Rat Interleukin 10 (IL10). This antibody is labeled with Cy3.
Interleukin 10 (IL10) Polyclonal Antibody (Rat), HRP
4-PAA056Ra06-HRP
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Rat Interleukin 10 (IL10). This antibody is labeled with HRP.
Interleukin 10 (IL10) Polyclonal Antibody (Dog), FITC
4-PAA056Ca01-FITC
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Dog Interleukin 10 (IL10). This antibody is labeled with FITC.
Interleukin 10 (IL10) Polyclonal Antibody (Dog), FITC
4-PAA056Ca06-FITC
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Dog Interleukin 10 (IL10). This antibody is labeled with FITC.
Interleukin 10 (IL10) Polyclonal Antibody (Horse), PE
4-PAA056Eq01-PE
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Horse Interleukin 10 (IL10). This antibody is labeled with PE.
Interleukin 10 (IL10) Polyclonal Antibody (Human), PE
4-PAA056Hu01-PE
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Human Interleukin 10 (IL10). This antibody is labeled with PE.
Interleukin 10 (IL10) Polyclonal Antibody (Human), PE
4-PAA056Hu02-PE
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Human Interleukin 10 (IL10). This antibody is labeled with PE.
Interleukin 10 (IL10) Polyclonal Antibody (Human), PE
4-PAA056Hu06-PE
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Human Interleukin 10 (IL10). This antibody is labeled with PE.
Interleukin 10 (IL10) Polyclonal Antibody (Mouse), PE
4-PAA056Mu01-PE
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Mouse Interleukin 10 (IL10). This antibody is labeled with PE.
Interleukin 10 (IL10) Polyclonal Antibody (Rat), FITC
4-PAA056Ra01-FITC
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Rat Interleukin 10 (IL10). This antibody is labeled with FITC.
Interleukin 10 (IL10) Polyclonal Antibody (Rat), FITC
4-PAA056Ra06-FITC
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Rat Interleukin 10 (IL10). This antibody is labeled with FITC.
Interleukin 10 (IL10) Polyclonal Antibody (Rabbit), PE
4-PAA056Rb51-PE
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20ul 100ul 200ul 1ml 10ml
Description: A Guinea polyclonal antibody against Rabbit Interleukin 10 (IL10). This antibody is labeled with PE.
Interleukin 10 (IL10) Polyclonal Antibody (Bovine), PE
4-PAA056Bo01-PE
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Bovine Interleukin 10 (IL10). This antibody is labeled with PE.
Interleukin 10 (IL10) Polyclonal Antibody (Horse), APC
4-PAA056Eq01-APC
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Horse Interleukin 10 (IL10). This antibody is labeled with APC.
Interleukin 10 (IL10) Polyclonal Antibody (Horse), Cy3
4-PAA056Eq01-Cy3
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Horse Interleukin 10 (IL10). This antibody is labeled with Cy3.
Interleukin 10 (IL10) Polyclonal Antibody (Horse), HRP
4-PAA056Eq01-HRP
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Horse Interleukin 10 (IL10). This antibody is labeled with HRP.
Interleukin 10 (IL10) Polyclonal Antibody (Gallus), PE
4-PAA056Ga01-PE
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Gallus Interleukin 10 (IL10). This antibody is labeled with PE.
Interleukin 10 (IL10) Polyclonal Antibody (Human), APC
4-PAA056Hu01-APC
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Human Interleukin 10 (IL10). This antibody is labeled with APC.
Interleukin 10 (IL10) Polyclonal Antibody (Human), Cy3
4-PAA056Hu01-Cy3
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Human Interleukin 10 (IL10). This antibody is labeled with Cy3.
Interleukin 10 (IL10) Polyclonal Antibody (Human), HRP
4-PAA056Hu01-HRP
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20ul 100ul 200ul 1ml 10ml
Description: A Rabbit polyclonal antibody against Human Interleukin 10 (IL10). This antibody is labeled with HRP.
Overall, our results suggest that human and mouse IL-5 mRNA alternative splice isoforms, which lost exon-2, however, expressed at the protein level. However, a more comprehensive study would be required to evaluate the expression of IL-5δ2, regulatory, biological function and clinical significance.
 Polyclonal Antibody)
 Polyclonal Antibody (Dog))
 Polyclonal Antibody (Rat))
)
 Polyclonal Antibody (Horse))
 Polyclonal Antibody (Human))
 Polyclonal Antibody (Mouse))
 Polyclonal Antibody (Bovine))
 Polyclonal Antibody (Gallus))
 Polyclonal Antibody (Rabbit))
 Polyclonal Antibody (Dog), PE)
 Polyclonal Antibody (Rat), PE)
 Polyclonal Antibody (Dog), APC)
 Polyclonal Antibody (Dog), Cy3)
 Polyclonal Antibody (Dog), HRP)
 Polyclonal Antibody (Rat), APC)
 Polyclonal Antibody (Rat), Cy3)
 Polyclonal Antibody (Rat), HRP)
 Polyclonal Antibody (Dog), FITC)
 Polyclonal Antibody (Horse), PE)
 Polyclonal Antibody (Human), PE)
 Polyclonal Antibody (Mouse), PE)
 Polyclonal Antibody (Rat), FITC)
 Polyclonal Antibody (Rabbit), PE)
 Polyclonal Antibody (Bovine), PE)
 Polyclonal Antibody (Horse), APC)
 Polyclonal Antibody (Horse), Cy3)
 Polyclonal Antibody (Horse), HRP)
 Polyclonal Antibody (Gallus), PE)
 Polyclonal Antibody (Human), APC)
 Polyclonal Antibody (Human), Cy3)
 Polyclonal Antibody (Human), HRP)
